Explore GCH1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T28226
|
| Target Name |
GCH1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2643
|
| Gene ID |
100050163 (Equus caballus), 101092120 (Felis catus), 14528 (Mus musculus), 2643 (Homo sapiens)
286815 (Bos taurus), 29244 (Rattus norvegicus), 609393 (Canis lupus familiaris), 695675 (Macaca mulatta)
|
| Target Alternative Names |
DYT14,DYT5,DYT5a,GCH,GCH1,GTP cyclohydrolase 1,GTP cyclohydrolase I (GTP-CH-I),GTP-CH,GTP-CH-1,GTP-CH-I,GTPCH,GTPCH-1,GTPCH1,Gch,Gch1,HPABH4B
|
| Uniprot Accession |
Q05915,P30793,P22288
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Metabolic pathways
|
| Gene Ensembl |
ENSECAG00000015025, ENSMUSG00000037580, ENSG00000131979, ENSBTAG00000040151, ENSCAFG00845014724, ENSMMUG00000004084
|
Pre-made viral vector of GCH1 cDNA Clones/ORF Plasmid
GCH1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2643 | Pre-made Human GCH1/GCH/DYT5 siRNA oligo Duplex | 2643 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29244 | Pre-made Rat Gch1/Gch/GTPCH siRNA oligo Duplex | 29244 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14528 | Pre-made Mouse Gch1/Gch/GTPCH siRNA oligo Duplex | 14528 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo695675 | Pre-made Cynomolgus/Rhesus macaque GCH1 siRNA oligo Duplex | 695675 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101092120 | Pre-made Cat/Feline GCH1 siRNA oligo Duplex | 101092120 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo609393 | Pre-made Dog/Canine GCH1 siRNA oligo Duplex | 609393 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo286815 | Pre-made Bovines/Cattle GCH1 siRNA oligo Duplex | 286815 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100050163 | Pre-made Equine/Horse GCH1 siRNA oligo Duplex | 100050163 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
GCH1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T28226-Ab | Human | Anti-Human GCH1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T28226-Ab | Rat | Anti-Rat GCH1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T28226-Ab | Mouse | Anti-Mouse GCH1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T28226-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque GCH1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T28226-Ab | Cat/Feline | Anti-Cat/Feline GCH1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T28226-Ab | Dog/Canine | Anti-Dog/Canine GCH1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T28226-Ab | Bovines/Cattle | Anti-Bovines/Cattle GCH1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T28226-Ab | Equine/Horse | Anti-Equine/Horse GCH1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GCH1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T28226-Ag | Human | Human GCH1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T28226-Ag | Rat | Rat GCH1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T28226-Ag | Mouse | Mouse GCH1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T28226-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque GCH1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T28226-Ag | Cat/Feline | Cat/Feline GCH1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T28226-Ag | Dog/Canine | Dog/Canine GCH1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T28226-Ag | Bovines/Cattle | Bovines/Cattle GCH1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T28226-Ag | Equine/Horse | Equine/Horse GCH1 recombinant protein | Mammalian cell | Detail |
