Recombinant multi-species MGMT protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MGMT protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015]
The Alternative Names of target: 6-O-methylguanine-DNA methyltransferase (MGMT),AGT,Agat,MGMT,Methylated-DNA--protein-cysteine methyltransferase,Mgmt,O-6-methylguanine-DNA-alkyltransferase

Target products collectionGo to MGMT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T24587-Ag-1/ GM-Tg-hg-T24587-Ag-2 Human MGMT protein Human
GM-Tg-rg-T24587-Ag-1/ GM-Tg-rg-T24587-Ag-2 Rat MGMT protein Rat
GM-Tg-mg-T24587-Ag-1/ GM-Tg-mg-T24587-Ag-2 Mouse MGMT protein Mouse
GM-Tg-cynog-T24587-Ag-1/ GM-Tg-cynog-T24587-Ag-2 Cynomolgus/Rhesus macaque MGMT protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T24587-Ag-1/ GM-Tg-felg-T24587-Ag-2 Feline MGMT protein Feline
GM-Tg-cang-T24587-Ag-1/ GM-Tg-cang-T24587-Ag-2 Canine MGMT protein Canine
GM-Tg-bovg-T24587-Ag-1/ GM-Tg-bovg-T24587-Ag-2 Bovine MGMT protein Bovine
GM-Tg-equg-T24587-Ag-1/ GM-Tg-equg-T24587-Ag-2 Equine MGMT protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T24587-Ag-1/ GM-Tg-hg-T24587-Ag-2; GM-Tg-rg-T24587-Ag-1/ GM-Tg-rg-T24587-Ag-2;
GM-Tg-mg-T24587-Ag-1/ GM-Tg-mg-T24587-Ag-2; GM-Tg-cynog-T24587-Ag-1/ GM-Tg-cynog-T24587-Ag-2;
GM-Tg-felg-T24587-Ag-1/ GM-Tg-felg-T24587-Ag-2; GM-Tg-cang-T24587-Ag-1/ GM-Tg-cang-T24587-Ag-2;
GM-Tg-bovg-T24587-Ag-1/ GM-Tg-bovg-T24587-Ag-2; GM-Tg-equg-T24587-Ag-1/ GM-Tg-equg-T24587-Ag-2
Products Name MGMT protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name MGMT
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MGMT protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.