Recombinant multi-species SERPING1/C1 Inactivator protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SERPING1/C1 Inactivator protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its encoded protein, C1 inhibitor, inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. It is synthesized in the liver, and its deficiency is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, May 2020]
The Alternative Names of target: C1 Inactivator,C1 Inh,C1 esterase inhibitor,C1-IA,C1-inhibiting factor,C1IN,C1INH,C1INH.,C1Inh,C1NH,C1nh,HAE1,HAE2,Plasma protease C1 inhibitor,SERPING1,Serpin G1,Serping1
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Product information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T24211-Ag-1/ GM-Tg-hg-T24211-Ag-2 | Human SERPING1/C1 Inactivator protein | Human |
| GM-Tg-rg-T24211-Ag-1/ GM-Tg-rg-T24211-Ag-2 | Rat SERPING1/C1 Inactivator protein | Rat |
| GM-Tg-mg-T24211-Ag-1/ GM-Tg-mg-T24211-Ag-2 | Mouse SERPING1/C1 Inactivator protein | Mouse |
| GM-Tg-cynog-T24211-Ag-1/ GM-Tg-cynog-T24211-Ag-2 | Cynomolgus/Rhesus macaque SERPING1/C1 Inactivator protein | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T24211-Ag-1/ GM-Tg-felg-T24211-Ag-2 | Feline SERPING1/C1 Inactivator protein | Feline |
| GM-Tg-cang-T24211-Ag-1/ GM-Tg-cang-T24211-Ag-2 | Canine SERPING1/C1 Inactivator protein | Canine |
| GM-Tg-bovg-T24211-Ag-1/ GM-Tg-bovg-T24211-Ag-2 | Bovine SERPING1/C1 Inactivator protein | Bovine |
| GM-Tg-equg-T24211-Ag-1/ GM-Tg-equg-T24211-Ag-2 | Equine SERPING1/C1 Inactivator protein | Equine |
Size: 1mg | 10mg | 100mg
Product Description
| Catalog No. |
GM-Tg-hg-T24211-Ag-1/ GM-Tg-hg-T24211-Ag-2;
GM-Tg-rg-T24211-Ag-1/ GM-Tg-rg-T24211-Ag-2;
GM-Tg-mg-T24211-Ag-1/ GM-Tg-mg-T24211-Ag-2; GM-Tg-cynog-T24211-Ag-1/ GM-Tg-cynog-T24211-Ag-2; GM-Tg-felg-T24211-Ag-1/ GM-Tg-felg-T24211-Ag-2; GM-Tg-cang-T24211-Ag-1/ GM-Tg-cang-T24211-Ag-2; GM-Tg-bovg-T24211-Ag-1/ GM-Tg-bovg-T24211-Ag-2; GM-Tg-equg-T24211-Ag-1/ GM-Tg-equg-T24211-Ag-2 |
| Products Name | SERPING1/C1 Inactivator protein |
| Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
| Target Name | SERPING1/C1 Inactivator |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
| Tag | His |
| Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SERPING1/C1 Inactivator protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution |
Lyophilized from GM's Protein Stability Buffer2
(PSB2,Confidential Ingredients) or PBS
(pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
About Gmab

GMab, developed by GeneMedi, constitutes an
advanced library of recombinant
monoclonal antibodies, each meticulously
designed to target specific molecular
entities. Leveraging the sophisticated
capabilities of GM’s Taurus™ and LIBRA™
platforms, GMab synthesizes antibodies
characterized by high binding affinity,
exceptional physicochemical stability, and
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Through
expression in mammalian cell lines, GMab has
been established as a paradigmatic
reference antibody. It holds significance in
myriad domains of biological drug
discovery, encompassing cellular cultivation,
innovative assay methodologies,
strategic animal model systematization, in-depth
pharmacokinetic & pharmacodynamic
(PK/PD) modeling, and intricate mechanism of
action (MOA) investigations.