Recombinant multi-species RAF1/c-RAF protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine RAF1/c-RAF protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
The Alternative Names of target: RAF1, c-RAF,RAF proto-oncogene serine/threonine-protein kinase,Proto-oncogene c-RAF (cRaf), Raf-1,NS5,CRAF,Raf-1,c-Raf,CMD1NN

Target products collectionGo to RAF1/c-RAF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T23673-Ab-1/ GM-Tg-hg-T23673-Ab-2 Human RAF1/c-RAF protein Human
GM-Tg-rg-T23673-Ab-1/ GM-Tg-rg-T23673-Ab-2 Rat RAF1/c-RAF protein Rat
GM-Tg-mg-T23673-Ab-1/ GM-Tg-mg-T23673-Ab-2 Mouse RAF1/c-RAF protein Mouse
GM-Tg-cynog-T23673-Ab-1/ GM-Tg-cynog-T23673-Ab-2 Cynomolgus/Rhesus macaque RAF1/c-RAF monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T23673-Ab-1/ GM-Tg-felg-T23673-Ab-2 Feline RAF1/c-RAF protein Feline
GM-Tg-cang-T23673-Ab-1/ GM-Tg-cang-T23673-Ab-2 Canine RAF1/c-RAF protein Canine
GM-Tg-bovg-T23673-Ab-1/ GM-Tg-bovg-T23673-Ab-2 Bovine RAF1/c-RAF protein Bovine
GM-Tg-equg-T23673-Ab-1/ GM-Tg-equg-T23673-Ab-2 Equine RAF1/c-RAF protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T23673-Ab-1/ GM-Tg-hg-T23673-Ab-2; GM-Tg-rg-T23673-Ab-1/ GM-Tg-rg-T23673-Ab-2;
GM-Tg-mg-T23673-Ab-1/ GM-Tg-mg-T23673-Ab-2; GM-Tg-cynog-T23673-Ab-1/ GM-Tg-cynog-T23673-Ab-2;
GM-Tg-felg-T23673-Ab-1/ GM-Tg-felg-T23673-Ab-2; GM-Tg-cang-T23673-Ab-1/ GM-Tg-cang-T23673-Ab-2;
GM-Tg-bovg-T23673-Ab-1/ GM-Tg-bovg-T23673-Ab-2; GM-Tg-equg-T23673-Ab-1/ GM-Tg-equg-T23673-Ab-2
Products Name RAF1/c-RAF protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name RAF1/c-RAF
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine RAF1/c-RAF protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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