Recombinant multi-species HIF2α/EPAS1/HIF-2A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HIF2α/EPAS1/HIF-2A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009]
The Alternative Names of target: Basic-helix-loop-helix-PAS protein MOP2,Class E basic helix-loop-helix protein 73 (bHLHe73),ECYT4,EPAS-1,EPAS1,Endothelial PAS domain-containing protein 1,Epas1,HIF-1-alpha-like factor (HLF),HIF-2 alpha,HIF-2A,HIF-2alpha,HIF2 alpha,HIF2-alpha),HIF2A,HIF2α,HLF,HRF,Hif2a,Hypoxia-inducible factor 2-alpha (HIF-2-alpha,MOP2,Member of PAS protein 2,PAS domain-containing protein 2,PASD2,bHLHe73

Target products collectionGo to HIF2α/EPAS1/HIF-2A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T21123-Ag-1/ GM-Tg-hg-T21123-Ag-2 Human HIF2α/EPAS1/HIF-2A protein Human
GM-Tg-rg-T21123-Ag-1/ GM-Tg-rg-T21123-Ag-2 Rat HIF2α/EPAS1/HIF-2A protein Rat
GM-Tg-mg-T21123-Ag-1/ GM-Tg-mg-T21123-Ag-2 Mouse HIF2α/EPAS1/HIF-2A protein Mouse
GM-Tg-cynog-T21123-Ag-1/ GM-Tg-cynog-T21123-Ag-2 Cynomolgus/Rhesus macaque HIF2α/EPAS1/HIF-2A protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T21123-Ag-1/ GM-Tg-felg-T21123-Ag-2 Feline HIF2α/EPAS1/HIF-2A protein Feline
GM-Tg-cang-T21123-Ag-1/ GM-Tg-cang-T21123-Ag-2 Canine HIF2α/EPAS1/HIF-2A protein Canine
GM-Tg-bovg-T21123-Ag-1/ GM-Tg-bovg-T21123-Ag-2 Bovine HIF2α/EPAS1/HIF-2A protein Bovine
GM-Tg-equg-T21123-Ag-1/ GM-Tg-equg-T21123-Ag-2 Equine HIF2α/EPAS1/HIF-2A protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T21123-Ag-1/ GM-Tg-hg-T21123-Ag-2; GM-Tg-rg-T21123-Ag-1/ GM-Tg-rg-T21123-Ag-2;
GM-Tg-mg-T21123-Ag-1/ GM-Tg-mg-T21123-Ag-2; GM-Tg-cynog-T21123-Ag-1/ GM-Tg-cynog-T21123-Ag-2;
GM-Tg-felg-T21123-Ag-1/ GM-Tg-felg-T21123-Ag-2; GM-Tg-cang-T21123-Ag-1/ GM-Tg-cang-T21123-Ag-2;
GM-Tg-bovg-T21123-Ag-1/ GM-Tg-bovg-T21123-Ag-2; GM-Tg-equg-T21123-Ag-1/ GM-Tg-equg-T21123-Ag-2
Products Name HIF2α/EPAS1/HIF-2A protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name HIF2α/EPAS1/HIF-2A
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HIF2α/EPAS1/HIF-2A protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.