Recombinant multi-species P62/SQSTM1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine P62/SQSTM1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
The Alternative Names of target: A170,DMRV,EBI3-associated protein of 60 kDa (EBIAP,EBIAP,FTDALS3,NADGP,OSF-6,OSIL,Osi,P62,PDB3,Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa,SQSTM1,STAP,STONE14,Sequestosome-1,Sqstm1,Ubiquitin-binding protein p62 (p62),ZIP,ZIP3,p60,p60),p62,p62B
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Product information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T17367-Ag-1/ GM-Tg-hg-T17367-Ag-2 | Human P62/SQSTM1 protein | Human |
| GM-Tg-rg-T17367-Ag-1/ GM-Tg-rg-T17367-Ag-2 | Rat P62/SQSTM1 protein | Rat |
| GM-Tg-mg-T17367-Ag-1/ GM-Tg-mg-T17367-Ag-2 | Mouse P62/SQSTM1 protein | Mouse |
| GM-Tg-cynog-T17367-Ag-1/ GM-Tg-cynog-T17367-Ag-2 | Cynomolgus/Rhesus macaque P62/SQSTM1 protein | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T17367-Ag-1/ GM-Tg-felg-T17367-Ag-2 | Feline P62/SQSTM1 protein | Feline |
| GM-Tg-cang-T17367-Ag-1/ GM-Tg-cang-T17367-Ag-2 | Canine P62/SQSTM1 protein | Canine |
| GM-Tg-bovg-T17367-Ag-1/ GM-Tg-bovg-T17367-Ag-2 | Bovine P62/SQSTM1 protein | Bovine |
| GM-Tg-equg-T17367-Ag-1/ GM-Tg-equg-T17367-Ag-2 | Equine P62/SQSTM1 protein | Equine |
Size: 1mg | 10mg | 100mg
Product Description
| Catalog No. |
GM-Tg-hg-T17367-Ag-1/ GM-Tg-hg-T17367-Ag-2;
GM-Tg-rg-T17367-Ag-1/ GM-Tg-rg-T17367-Ag-2;
GM-Tg-mg-T17367-Ag-1/ GM-Tg-mg-T17367-Ag-2; GM-Tg-cynog-T17367-Ag-1/ GM-Tg-cynog-T17367-Ag-2; GM-Tg-felg-T17367-Ag-1/ GM-Tg-felg-T17367-Ag-2; GM-Tg-cang-T17367-Ag-1/ GM-Tg-cang-T17367-Ag-2; GM-Tg-bovg-T17367-Ag-1/ GM-Tg-bovg-T17367-Ag-2; GM-Tg-equg-T17367-Ag-1/ GM-Tg-equg-T17367-Ag-2 |
| Products Name | P62/SQSTM1 protein |
| Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
| Target Name | P62/SQSTM1 |
| Protein Sub-location | Introcelluar Protein |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
| Tag | His |
| Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine P62/SQSTM1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution |
Lyophilized from GM's Protein Stability Buffer2
(PSB2,Confidential Ingredients) or PBS
(pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
About Gmab

GMab, developed by GeneMedi, constitutes an
advanced library of recombinant
monoclonal antibodies, each meticulously
designed to target specific molecular
entities. Leveraging the sophisticated
capabilities of GM’s Taurus™ and LIBRA™
platforms, GMab synthesizes antibodies
characterized by high binding affinity,
exceptional physicochemical stability, and
optimal developability profiles.
Through
expression in mammalian cell lines, GMab has
been established as a paradigmatic
reference antibody. It holds significance in
myriad domains of biological drug
discovery, encompassing cellular cultivation,
innovative assay methodologies,
strategic animal model systematization, in-depth
pharmacokinetic & pharmacodynamic
(PK/PD) modeling, and intricate mechanism of
action (MOA) investigations.