P62/SQSTM1 Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein
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Target
sublocation: Introcelluar Protein.
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
| Target ID | GM-T17367 |
| Target Name | P62/SQSTM1 |
|
Gene Group ldentifer （Target Gene ID in Homo species) |
8878 |
| Gene ID |
100067231 (Equus caballus), 101085431 (Felis catus), 113894 (Rattus norvegicus), 18412 (Mus musculus) 338045 (Bos taurus), 481459 (Canis lupus familiaris), 705481 (Macaca mulatta), 8878 (Homo sapiens) |
| Target Alternative Names | A170,DMRV,EBI3-associated protein of 60 kDa (EBIAP,EBIAP,FTDALS3,NADGP,OSF-6,OSIL,Osi,P62,PDB3,Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa,SQSTM1,STAP,STONE14,Sequestosome-1,Sqstm1,Ubiquitin-binding protein p62 (p62),ZIP,ZIP3,p60,p60),p62,p62B |
| Uniprot Accession | O08623,Q64337,Q13501 |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | cancer |
| Disease from KEGG | Cellular senescence, Osteoclast differentiation, Fluid shear stress and atherosclerosis |
| Gene Ensembl | ENSECAG00000020929, ENSMUSG00000015837, ENSBTAG00000015591, ENSCAFG00845007599, ENSMMUG00000021055, ENSG00000161011 |
| Target Classification | Tumor-associated antigen (TAA) |
Pre-made viral vector of P62/SQSTM1 cDNA Clones/ORF Plasmid
| Cat No. | Product Name | NMID | GeneID | Species | Type | Marker | Fusion Tag | Promoter | Detail |
|---|---|---|---|---|---|---|---|---|---|
| pGMLP001154 | Human SQSTM1/A170/DMRV Lentivirus plasmid | NM_001142298.1 | 8878 | Human | Lentivirus plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| pGMPC001112 | Human SQSTM1/A170/DMRV Mammalian (Non-Viral Vector) plasmid | NM_003900.5 | 8878 | Human | Mammalian (Non-Viral Vector) plasmid | Null | HA (C-Terminal) | CMV | Detail |
| vGMAP-SPh-254 | Human SQSTM1/p60/p62 Adenovirus particle | BC003139 | 8878 | Human | Adenovirus particle | EGFP | 3xflag (C-Terminal) | EF1 | Detail |
| vGMLP-SPh-114 | Human SQSTM1/p60/p62 Lentivirus particle | BC003139 | 8878 | Human | Lentivirus particle | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| vGMAP000095 | Human SQSTM1/p60/p62 Adenovirus particle | BC003139 | 8878 | Human | Adenovirus particle | GFP | 3xflag (C-Terminal) | EF1 | Detail |
| vGMLV000821 | Human SQSTM1/A170/DMRV Lentivirus particle | NM_003900.4 | 8878 | Human | Lentivirus particle | mCherry | 3xflag (C-Terminal) | CMV | Detail |
| vGMLV000807 | Human SQSTM1/A170/DMRV Lentivirus particle | NM_003900.5 | 8878 | Human | Lentivirus particle | mCherry | 3xflag (C-Terminal) | CMV | Detail |
| vGMLP003899 | Human SQSTM1/p60/p62 Lentivirus particle | BC019111.1 | 8878 | Human | Lentivirus particle | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| vGMLP001154 | Human SQSTM1/A170/DMRV Lentivirus particle | NM_001142298.1 | 8878 | Human | Lentivirus particle | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| pGMPC004863 | Human SQSTM1/A170/DMRV Mammalian (Non-Viral Vector) plasmid | NM_003900.5 | 8878 | Human | Mammalian (Non-Viral Vector) plasmid | Null | HA (C-Terminal) | CMV | Detail |
| pGMLP003899 | Human SQSTM1/p60/p62 Lentivirus plasmid | BC019111.1 | 8878 | Human | Lentivirus plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| pGMPC001423 | Human SQSTM1/A170/DMRV Mammalian (Non-Viral Vector) plasmid | NM_003900.5 | 8878 | Human | Mammalian (Non-Viral Vector) plasmid | EGFP | 3xflag (C-Terminal) | EF1 | Detail |
| pGMLV000807 | Human SQSTM1/A170/DMRV Lentivirus plasmid | NM_003900.5 | 8878 | Human | Lentivirus plasmid | mCherry | 3xflag (C-Terminal) | CMV | Detail |
| pGMAP-SPh-254 | Human SQSTM1/p60/p62 Adenovirus plasmid | BC003139 | 8878 | Human | Adenovirus plasmid | EGFP | 3xflag (C-Terminal) | EF1 | Detail |
| pGMLP-SPh-114 | Human SQSTM1/p60/p62 Lentivirus plasmid | BC003139 | 8878 | Human | Lentivirus plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| pGMLV000821 | Human SQSTM1/A170/DMRV Lentivirus plasmid | NM_003900.4 | 8878 | Human | Lentivirus plasmid | mCherry | 3xflag (C-Terminal) | CMV | Detail |
| pGMAP000095 | Human SQSTM1/p60/p62 Adenovirus plasmid | BC003139 | 8878 | Human | Adenovirus plasmid | GFP | 3xflag (C-Terminal) | EF1 | Detail |
| pGMLP-SPm-124 | Mouse Sqstm1/A170/OSF-6 Lentivirus plasmid | NM_011018 | 18412 | Mouse | Lentivirus plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| vGMAAV000320 | Mouse Sqstm1/A170/OSF-6 Adeno-associate virus(AAV) particle | NM_011018.3 | 18412 | Mouse | Adeno-associate virus(AAV) particle | GFP | 3xflag (C-Terminal) | hSyn | Detail |
| vGMAP-SPm-230 | Mouse Sqstm1/A170/OSF-6 Adenovirus particle | NM_011018 | 18412 | Mouse | Adenovirus particle | EGFP | 3xflag (C-Terminal) | EF1 | Detail |
| vGMLP-SPm-124 | Mouse Sqstm1/A170/OSF-6 Lentivirus particle | NM_011018 | 18412 | Mouse | Lentivirus particle | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| vGMLP-SPm-103 | Mouse Sqstm1/A170/OSF-6 Lentivirus particle | NM_011018 | 18412 | Mouse | Lentivirus particle | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| vGMLPm004881 | Mouse Sqstm1/A170/OSF-6 Lentivirus particle | NM_011018 | 18412 | Mouse | Lentivirus particle | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| pGMAD000242 | Mouse Sqstm1/A170/OSF-6 Adenovirus plasmid | NM_011018.3 | 18412 | Mouse | Adenovirus plasmid | GFP | 3xflag (C-Terminal) | EF1 | Detail |
| pGMAD000460 | Mouse Sqstm1/A170/OSF-6 Adenovirus plasmid | NM_011018.3 | 18412 | Mouse | Adenovirus plasmid | GFP | 3xflag (C-Terminal) | EF1 | Detail |
| vGMAD000460 | Mouse Sqstm1/A170/OSF-6 Adenovirus particle | NM_011018.3 | 18412 | Mouse | Adenovirus particle | GFP | 3xflag (C-Terminal) | EF1 | Detail |
| vGMAD000242 | Mouse Sqstm1/A170/OSF-6 Adenovirus particle | NM_011018.3 | 18412 | Mouse | Adenovirus particle | GFP | 3xflag (C-Terminal) | EF1 | Detail |
| pGMAP-SPm-230 | Mouse Sqstm1/A170/OSF-6 Adenovirus plasmid | NM_011018 | 18412 | Mouse | Adenovirus plasmid | EGFP | 3xflag (C-Terminal) | EF1 | Detail |
| pGMAAV000320 | Mouse Sqstm1/A170/OSF-6 Adeno-associate virus(AAV) plasmid | NM_011018.3 | 18412 | Mouse | Adeno-associate virus(AAV) plasmid | GFP | 3xflag (C-Terminal) | hSyn | Detail |
| pGMLPm004881 | Mouse Sqstm1/A170/OSF-6 Lentivirus plasmid | NM_011018 | 18412 | Mouse | Lentivirus plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| pGMPC001566 | Mouse Sqstm1/A170/OSF-6 Mammalian (Non-Viral Vector) plasmid | NM_011018.3 | 18412 | Mouse | Mammalian (Non-Viral Vector) plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| pGMLP-SPm-103 | Mouse Sqstm1/A170/OSF-6 Lentivirus plasmid | NM_011018 | 18412 | Mouse | Lentivirus plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| pGMPC000569 | Mouse Sqstm1/A17/A170 Mammalian (Non-Viral Vector) plasmid | NM_011018 | 18412 | Mouse | Mammalian (Non-Viral Vector) plasmid | Null | 3xflag (C-Terminal) | CMV | Detail |
| pGMAP-SPm-251 | Mouse Sqstm1/A170/OSF-6 Adenovirus plasmid | NM_011018 | 18412 | Mouse | Adenovirus plasmid | EGFP | 3xflag (C-Terminal) | EF1 | Detail |
| vGMAP-SPm-251 | Mouse Sqstm1/A170/OSF-6 Adenovirus particle | NM_011018 | 18412 | Mouse | Adenovirus particle | EGFP | 3xflag (C-Terminal) | EF1 | Detail |
P62/SQSTM1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|---|---|---|---|---|
| pGMoligo8878 | Pre-made Human SQSTM1/p60/p62 siRNA oligo Duplex | 8878 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo113894 | Pre-made Rat Sqstm1/Osi/ZIP siRNA oligo Duplex | 113894 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18412 | Pre-made Mouse Sqstm1/Osi/p62 siRNA oligo Duplex | 18412 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo705481 | Pre-made Cynomolgus/Rhesus macaque SQSTM1 siRNA oligo Duplex | 705481 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101085431 | Pre-made Cat/Feline SQSTM1 siRNA oligo Duplex | 101085431 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo481459 | Pre-made Dog/Canine SQSTM1 siRNA oligo Duplex | 481459 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo338045 | Pre-made Bovines/Cattle SQSTM1 siRNA oligo Duplex | 338045 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100067231 | Pre-made Equine/Horse SQSTM1 siRNA oligo Duplex | 100067231 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
P62/SQSTM1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|---|---|---|---|---|
| GM-Tg-hg-T17367-Ab | Human | Anti-Human P62/SQSTM1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T17367-Ab | Rat | Anti-Rat P62/SQSTM1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T17367-Ab | Mouse | Anti-Mouse P62/SQSTM1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T17367-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque P62/SQSTM1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T17367-Ab | Cat/Feline | Anti-Cat/Feline P62/SQSTM1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T17367-Ab | Dog/Canine | Anti-Dog/Canine P62/SQSTM1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T17367-Ab | Bovines/Cattle | Anti-Bovines/Cattle P62/SQSTM1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T17367-Ab | Equine/Horse | Anti-Equine/Horse P62/SQSTM1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
P62/SQSTM1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|---|---|---|---|
| GM-Tg-hg-T17367-Ag | Human | Human P62/SQSTM1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T17367-Ag | Rat | Rat P62/SQSTM1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T17367-Ag | Mouse | Mouse P62/SQSTM1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T17367-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque P62/SQSTM1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T17367-Ag | Cat/Feline | Cat/Feline P62/SQSTM1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T17367-Ag | Dog/Canine | Dog/Canine P62/SQSTM1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T17367-Ag | Bovines/Cattle | Bovines/Cattle P62/SQSTM1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T17367-Ag | Equine/Horse | Equine/Horse P62/SQSTM1 recombinant protein | Mammalian cell | Detail |