Recombinant multi-species LEPR/Leptin R/CD295 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine LEPR/Leptin R/CD295 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]
The Alternative Names of target: B219,CD295,Fa,HuB219,LEP-R,LEPR,LEPRD,LEPROT,Lepr,Leprb,Leptin R,Leptin receptor,Modb1,OB receptor (OB-R),OB-R,OB-RGRP,OBR,Ob-R,Ob-RM,ObRb,Obr,db,diabetes,obese-like,obl

Target products collectionGo to LEPR/Leptin R/CD295 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T17163-Ag-1/ GM-Tg-hg-T17163-Ag-2 Human LEPR/Leptin R/CD295 protein Human
GM-Tg-rg-T17163-Ag-1/ GM-Tg-rg-T17163-Ag-2 Rat LEPR/Leptin R/CD295 protein Rat
GM-Tg-mg-T17163-Ag-1/ GM-Tg-mg-T17163-Ag-2 Mouse LEPR/Leptin R/CD295 protein Mouse
GM-Tg-cynog-T17163-Ag-1/ GM-Tg-cynog-T17163-Ag-2 Cynomolgus/Rhesus macaque LEPR/Leptin R/CD295 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T17163-Ag-1/ GM-Tg-felg-T17163-Ag-2 Feline LEPR/Leptin R/CD295 protein Feline
GM-Tg-cang-T17163-Ag-1/ GM-Tg-cang-T17163-Ag-2 Canine LEPR/Leptin R/CD295 protein Canine
GM-Tg-bovg-T17163-Ag-1/ GM-Tg-bovg-T17163-Ag-2 Bovine LEPR/Leptin R/CD295 protein Bovine
GM-Tg-equg-T17163-Ag-1/ GM-Tg-equg-T17163-Ag-2 Equine LEPR/Leptin R/CD295 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T17163-Ag-1/ GM-Tg-hg-T17163-Ag-2; GM-Tg-rg-T17163-Ag-1/ GM-Tg-rg-T17163-Ag-2;
GM-Tg-mg-T17163-Ag-1/ GM-Tg-mg-T17163-Ag-2; GM-Tg-cynog-T17163-Ag-1/ GM-Tg-cynog-T17163-Ag-2;
GM-Tg-felg-T17163-Ag-1/ GM-Tg-felg-T17163-Ag-2; GM-Tg-cang-T17163-Ag-1/ GM-Tg-cang-T17163-Ag-2;
GM-Tg-bovg-T17163-Ag-1/ GM-Tg-bovg-T17163-Ag-2; GM-Tg-equg-T17163-Ag-1/ GM-Tg-equg-T17163-Ag-2
Products Name LEPR/Leptin R/CD295 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name LEPR/Leptin R/CD295
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine LEPR/Leptin R/CD295 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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