Recombinant multi-species P16-INK4A/CDKN2A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine P16-INK4A/CDKN2A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
The Alternative Names of target: ARF,CAI2,CDK4I,CDKN2,CDKN2A,CMM2,INK4,INK4A,MLM,MTS-1,MTS1,P14,P14ARF,P16,P16-INK4A,P16INK4,P16INK4A,P19,P19ARF,TP16

Target products collectionGo to P16-INK4A/CDKN2A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T16452-Ag-1/ GM-Tg-hg-T16452-Ag-2 Human P16-INK4A/CDKN2A protein Human
GM-Tg-rg-T16452-Ag-1/ GM-Tg-rg-T16452-Ag-2 Rat P16-INK4A/CDKN2A protein Rat
GM-Tg-mg-T16452-Ag-1/ GM-Tg-mg-T16452-Ag-2 Mouse P16-INK4A/CDKN2A protein Mouse
GM-Tg-cynog-T16452-Ag-1/ GM-Tg-cynog-T16452-Ag-2 Cynomolgus/Rhesus macaque P16-INK4A/CDKN2A protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T16452-Ag-1/ GM-Tg-felg-T16452-Ag-2 Feline P16-INK4A/CDKN2A protein Feline
GM-Tg-cang-T16452-Ag-1/ GM-Tg-cang-T16452-Ag-2 Canine P16-INK4A/CDKN2A protein Canine
GM-Tg-bovg-T16452-Ag-1/ GM-Tg-bovg-T16452-Ag-2 Bovine P16-INK4A/CDKN2A protein Bovine
GM-Tg-equg-T16452-Ag-1/ GM-Tg-equg-T16452-Ag-2 Equine P16-INK4A/CDKN2A protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T16452-Ag-1/ GM-Tg-hg-T16452-Ag-2; GM-Tg-rg-T16452-Ag-1/ GM-Tg-rg-T16452-Ag-2;
GM-Tg-mg-T16452-Ag-1/ GM-Tg-mg-T16452-Ag-2; GM-Tg-cynog-T16452-Ag-1/ GM-Tg-cynog-T16452-Ag-2;
GM-Tg-felg-T16452-Ag-1/ GM-Tg-felg-T16452-Ag-2; GM-Tg-cang-T16452-Ag-1/ GM-Tg-cang-T16452-Ag-2;
GM-Tg-bovg-T16452-Ag-1/ GM-Tg-bovg-T16452-Ag-2; GM-Tg-equg-T16452-Ag-1/ GM-Tg-equg-T16452-Ag-2
Products Name P16-INK4A/CDKN2A protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name P16-INK4A/CDKN2A
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine P16-INK4A/CDKN2A protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.