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Target
sublocation: Introcelluar Protein.
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
| Target ID |
GM-T16452
|
| Target Name |
P16-INK4A/CDKN2A
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1029
|
| Gene ID |
1029 (Homo sapiens)
|
| Target Alternative Names |
CDKN2A,ARF,MLM,P14,P16,P19,CAI2,CMM2,INK4,MTS1,TP16,CDK4I,CDKN2,INK4A,MTS-1,P14ARF,P19ARF,P16INK4,P16INK4A,P16-INK4A
|
| Uniprot Accession |
P42771,Q8N726
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer, Prostate Cancer, Skin cancer - melanoma
|
| Disease from KEGG |
Endocrine resistance, p53 signaling pathway, Cellular senescence, Cushing syndrome, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Pathways in cancer, Pancreatic cancer, Glioma, Melanoma, Bladder cancer, Chronic myeloid leukemia, Non-small cell lung cancer, Hepatocellular carcinoma
|
| Gene Ensembl |
ENSG00000147889
|
| Target Classification |
|
Pre-made viral vector of P16-INK4A/CDKN2A cDNA Clones/ORF Plasmid
P16-INK4A/CDKN2A siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1029 | Pre-made Human CDKN2A/ARF/MLM siRNA oligo Duplex | 1029 | Human | In-vitro grade; in-vivo grade | Detail |
P16-INK4A/CDKN2A antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T16452-Ab | Human | Anti-Human P16-INK4A/CDKN2A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
P16-INK4A/CDKN2A recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T16452-Ag | Human | Human P16-INK4A/CDKN2A recombinant protein | Mammalian cell | Detail |
