Recombinant multi-species P53/TP53 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine P53/TP53 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
The Alternative Names of target: Antigen NY-CO-13,BCC7,BMFS5,Cellular tumor antigen p53,LFS1,P53,Phosphoprotein p53,TP53,TRP53,Tp53,Trp53,Tumor suppressor p53,bbl,bfy,bhy,p44,p53

Target products collectionGo to P53/TP53 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T15739-Ag-1/ GM-Tg-hg-T15739-Ag-2 Human P53/TP53 protein Human
GM-Tg-rg-T15739-Ag-1/ GM-Tg-rg-T15739-Ag-2 Rat P53/TP53 protein Rat
GM-Tg-mg-T15739-Ag-1/ GM-Tg-mg-T15739-Ag-2 Mouse P53/TP53 protein Mouse
GM-Tg-cynog-T15739-Ag-1/ GM-Tg-cynog-T15739-Ag-2 Cynomolgus/Rhesus macaque P53/TP53 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T15739-Ag-1/ GM-Tg-felg-T15739-Ag-2 Feline P53/TP53 protein Feline
GM-Tg-cang-T15739-Ag-1/ GM-Tg-cang-T15739-Ag-2 Canine P53/TP53 protein Canine
GM-Tg-bovg-T15739-Ag-1/ GM-Tg-bovg-T15739-Ag-2 Bovine P53/TP53 protein Bovine
GM-Tg-equg-T15739-Ag-1/ GM-Tg-equg-T15739-Ag-2 Equine P53/TP53 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T15739-Ag-1/ GM-Tg-hg-T15739-Ag-2; GM-Tg-rg-T15739-Ag-1/ GM-Tg-rg-T15739-Ag-2;
GM-Tg-mg-T15739-Ag-1/ GM-Tg-mg-T15739-Ag-2; GM-Tg-cynog-T15739-Ag-1/ GM-Tg-cynog-T15739-Ag-2;
GM-Tg-felg-T15739-Ag-1/ GM-Tg-felg-T15739-Ag-2; GM-Tg-cang-T15739-Ag-1/ GM-Tg-cang-T15739-Ag-2;
GM-Tg-bovg-T15739-Ag-1/ GM-Tg-bovg-T15739-Ag-2; GM-Tg-equg-T15739-Ag-1/ GM-Tg-equg-T15739-Ag-2
Products Name P53/TP53 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name P53/TP53
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine P53/TP53 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.