Recombinant multi-species Caspase 8/p43/p18/CASP8 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Caspase 8/p43/p18/CASP8 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
The Alternative Names of target: ALPS2B,Apoptotic cysteine protease,Apoptotic protease Mch-5,CAP4,CASP-8,CASP8,Casp-8,Casp8,Caspase 8,Caspase-8,FADD-homologous ICE/ced-3-like protease,FADD-like ICE (FLICE),FLICE,ICE-like apoptotic protease 5,MACH,MCH5,MORT1-associated ced-3 homolog (MACH),Mch5,p18,p43

Target products collectionGo to Caspase 8/p43/p18/CASP8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T15700-Ag-1/ GM-Tg-hg-T15700-Ag-2 Human Caspase 8/p43/p18/CASP8 protein Human
GM-Tg-rg-T15700-Ag-1/ GM-Tg-rg-T15700-Ag-2 Rat Caspase 8/p43/p18/CASP8 protein Rat
GM-Tg-mg-T15700-Ag-1/ GM-Tg-mg-T15700-Ag-2 Mouse Caspase 8/p43/p18/CASP8 protein Mouse
GM-Tg-cynog-T15700-Ag-1/ GM-Tg-cynog-T15700-Ag-2 Cynomolgus/Rhesus macaque Caspase 8/p43/p18/CASP8 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T15700-Ag-1/ GM-Tg-felg-T15700-Ag-2 Feline Caspase 8/p43/p18/CASP8 protein Feline
GM-Tg-cang-T15700-Ag-1/ GM-Tg-cang-T15700-Ag-2 Canine Caspase 8/p43/p18/CASP8 protein Canine
GM-Tg-bovg-T15700-Ag-1/ GM-Tg-bovg-T15700-Ag-2 Bovine Caspase 8/p43/p18/CASP8 protein Bovine
GM-Tg-equg-T15700-Ag-1/ GM-Tg-equg-T15700-Ag-2 Equine Caspase 8/p43/p18/CASP8 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T15700-Ag-1/ GM-Tg-hg-T15700-Ag-2; GM-Tg-rg-T15700-Ag-1/ GM-Tg-rg-T15700-Ag-2;
GM-Tg-mg-T15700-Ag-1/ GM-Tg-mg-T15700-Ag-2; GM-Tg-cynog-T15700-Ag-1/ GM-Tg-cynog-T15700-Ag-2;
GM-Tg-felg-T15700-Ag-1/ GM-Tg-felg-T15700-Ag-2; GM-Tg-cang-T15700-Ag-1/ GM-Tg-cang-T15700-Ag-2;
GM-Tg-bovg-T15700-Ag-1/ GM-Tg-bovg-T15700-Ag-2; GM-Tg-equg-T15700-Ag-1/ GM-Tg-equg-T15700-Ag-2
Products Name Caspase 8/p43/p18/CASP8 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Caspase 8/p43/p18/CASP8
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Caspase 8/p43/p18/CASP8 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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