Caspase 8/p43/p18/CASP8 Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore Caspase 8/p43/p18/CASP8 gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Introcelluar Protein.
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]

Pre-made viral vector of Caspase 8/p43/p18/CASP8 cDNA Clones/ORF Plasmid

Caspase 8/p43/p18/CASP8 siRNA/miRNA/oligo for RNA interfence (RNAi)

Caspase 8/p43/p18/CASP8 antibody/GMab

Caspase 8/p43/p18/CASP8 recombinant protein