Recombinant multi-species TRAF6 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TRAF6 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain and mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. The protein encoded by this gene is a key molecule in antiviral innate and antigen-specific immune responses. [provided by RefSeq, Nov 2021]
The Alternative Names of target: 2310003F17Rik,C630032O20Rik,E3 ubiquitin-protein ligase TRAF6,Interleukin-1 signal transducer,MGC:3310,RING finger protein 85,RING-type E3 ubiquitin transferase TRAF6,RNF85,TNF receptor-associated factor 6,TRAF6,Traf6

Target products collectionGo to TRAF6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T15051-Ag-1/ GM-Tg-hg-T15051-Ag-2 Human TRAF6 protein Human
GM-Tg-rg-T15051-Ag-1/ GM-Tg-rg-T15051-Ag-2 Rat TRAF6 protein Rat
GM-Tg-mg-T15051-Ag-1/ GM-Tg-mg-T15051-Ag-2 Mouse TRAF6 protein Mouse
GM-Tg-cynog-T15051-Ag-1/ GM-Tg-cynog-T15051-Ag-2 Cynomolgus/Rhesus macaque TRAF6 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T15051-Ag-1/ GM-Tg-felg-T15051-Ag-2 Feline TRAF6 protein Feline
GM-Tg-cang-T15051-Ag-1/ GM-Tg-cang-T15051-Ag-2 Canine TRAF6 protein Canine
GM-Tg-bovg-T15051-Ag-1/ GM-Tg-bovg-T15051-Ag-2 Bovine TRAF6 protein Bovine
GM-Tg-equg-T15051-Ag-1/ GM-Tg-equg-T15051-Ag-2 Equine TRAF6 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T15051-Ag-1/ GM-Tg-hg-T15051-Ag-2; GM-Tg-rg-T15051-Ag-1/ GM-Tg-rg-T15051-Ag-2;
GM-Tg-mg-T15051-Ag-1/ GM-Tg-mg-T15051-Ag-2; GM-Tg-cynog-T15051-Ag-1/ GM-Tg-cynog-T15051-Ag-2;
GM-Tg-felg-T15051-Ag-1/ GM-Tg-felg-T15051-Ag-2; GM-Tg-cang-T15051-Ag-1/ GM-Tg-cang-T15051-Ag-2;
GM-Tg-bovg-T15051-Ag-1/ GM-Tg-bovg-T15051-Ag-2; GM-Tg-equg-T15051-Ag-1/ GM-Tg-equg-T15051-Ag-2
Products Name TRAF6 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name TRAF6
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TRAF6 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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