TRAF6 Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore TRAF6 gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Introcelluar Protein.
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain and mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. The protein encoded by this gene is a key molecule in antiviral innate and antigen-specific immune responses. [provided by RefSeq, Nov 2021]

Target ID	GM-T15051
Target Name	TRAF6
Gene Group ldentifer （Target Gene ID in Homo species)	7189
Gene ID	100052296 (Equus caballus), 100688110 (Canis lupus familiaris), 101099750 (Felis catus), 22034 (Mus musculus) 311245 (Rattus norvegicus), 539124 (Bos taurus), 716907 (Macaca mulatta), 7189 (Homo sapiens)
Target Alternative Names	2310003F17Rik,C630032O20Rik,E3 ubiquitin-protein ligase TRAF6,Interleukin-1 signal transducer,MGC:3310,RING finger protein 85,RING-type E3 ubiquitin transferase TRAF6,RNF85,TNF receptor-associated factor 6,TRAF6,Traf6
Uniprot Accession	P70196,B5DF45,Q3ZCC3,B6CJY5,Q9Y4K3
Protein Sub-location	Introcelluar Protein
Category	Therapeutics Target, Cytokine Target
Disease	cancer
Disease from KEGG	MAPK signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, IL-17 signaling pathway, Neurotrophin signaling pathway, Alcoholic liver disease, Pathogenic Escherichia coli infection, Pertussis, Yersinia infection, Leishmaniasis, Chagas disease, Toxoplasmosis, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Epstein-Barr virus infection, Pathways in cancer, Small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis
Gene Ensembl	ENSECAG00000021091, ENSCAFG00845020292, ENSMUSG00000027164, ENSBTAG00000036009, ENSMMUG00000018266, ENSG00000175104
Target Classification	Tumor-associated antigen (TAA)

Pre-made viral vector of TRAF6 cDNA Clones/ORF Plasmid

Cat No.	Product Name	NMID	GeneID	Species	Type	Marker	Fusion Tag	Promoter	Detail
pGMLP001351	Human TRAF6/MGC:3310/RNF85 Lentivirus plasmid	NM_145803	7189	Human	Lentivirus plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
pGMLV001820	Human TRAF6/MGC:3310/RNF85 Lentivirus plasmid	NM_145803	7189	Human	Lentivirus plasmid	ZsGreen	Null	CMV	Detail
vGMLV001820	Human TRAF6/MGC:3310/RNF85 Lentivirus particle	NM_145803	7189	Human	Lentivirus particle	ZsGreen	Null	CMV	Detail
vGMLP001351	Human TRAF6/MGC:3310/RNF85 Lentivirus particle	NM_145803	7189	Human	Lentivirus particle	ZsGreen	3xflag (C-Terminal)	CMV	Detail
pGMPC001068	Human TRAF6/MGC:3310/RNF85 Mammalian (Non-Viral Vector) plasmid	NM_145803.3	7189	Human	Mammalian (Non-Viral Vector) plasmid	ZsGreen	MYC (C-Terminal)	CMV	Detail
pGMPC001026	Human TRAF6/MGC:3310/RNF85 Mammalian (Non-Viral Vector) plasmid	NM_145803.3	7189	Human	Mammalian (Non-Viral Vector) plasmid	Null	MYC (C-Terminal)	CMV	Detail
vGMAD001019	Rat Traf6 Adenovirus particle	NM_001107754.2	311245	Rat	Adenovirus particle	EGFP	3xflag (C-Terminal)	EF1	Detail
pGMAD001019	Rat Traf6 Adenovirus plasmid	NM_001107754.2	311245	Rat	Adenovirus plasmid	EGFP	3xflag (C-Terminal)	EF1	Detail
pGMLPm001259	Mouse Traf6/2310003F17Rik/AI851288 Lentivirus plasmid	NM_009424	22034	Mouse	Lentivirus plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
pGMLPm005412	Mouse Traf6/2310003F17Rik/AI851288 Lentivirus plasmid	NM_001303273	22034	Mouse	Lentivirus plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
pGMPC000137	Mouse TRAF6/2310003F17Rik/AI851288 Mammalian (Non-Viral Vector) plasmid	NM_001303273.1	22034	Mouse	Mammalian (Non-Viral Vector) plasmid	EGFP	3xflag (C-Terminal)	EF1	Detail
pGMPC000245	Mouse Traf6 /2310003F17Rik/AI851288 Mammalian (Non-Viral Vector) plasmid	NM_001303273	22034	Mouse	Mammalian (Non-Viral Vector) plasmid	Null	HA (C-Terminal)	CMV	Detail
pGMAAV000779	Mouse Traf6/2310003F17Rik/AI851288 Adeno-associate virus(AAV) plasmid	NM_001303273.1	22034	Mouse	Adeno-associate virus(AAV) plasmid	EGFP	3xflag (C-Terminal)	CTNT	Detail
pGMAD000221	Mouse Traf6/2310003F17Rik/AI851288 Adenovirus plasmid	NM_009424.3	22034	Mouse	Adenovirus plasmid	Null	Null	CMV	Detail
pGMLV001965	Mouse Traf6/2310003F17Rik/AI851288 Lentivirus plasmid	NM_009424.3	22034	Mouse	Lentivirus plasmid	ZsGreen	MYC (C-Terminal)	CMV	Detail
vGMLV001965	Mouse Traf6/2310003F17Rik/AI851288 Lentivirus particle	NM_009424.3	22034	Mouse	Lentivirus particle	ZsGreen	MYC (C-Terminal)	CMV	Detail
vGMAD000221	Mouse Traf6/2310003F17Rik/AI851288 Adenovirus particle	NM_009424.3	22034	Mouse	Adenovirus particle	Null	Null	CMV	Detail
vGMAAV000779	Mouse Traf6/2310003F17Rik/AI851288 Adeno-associate virus(AAV) particle	NM_001303273.1	22034	Mouse	Adeno-associate virus(AAV) particle	EGFP	3xflag (C-Terminal)	CTNT	Detail
vGMLPm001259	Mouse Traf6/2310003F17Rik/AI851288 Lentivirus particle	NM_009424	22034	Mouse	Lentivirus particle	ZsGreen	3xflag (C-Terminal)	CMV	Detail
vGMLPm005412	Mouse Traf6/2310003F17Rik/AI851288 Lentivirus particle	NM_001303273	22034	Mouse	Lentivirus particle	ZsGreen	3xflag (C-Terminal)	CMV	Detail

TRAF6 siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.	Product Name	GeneID	Species	Grade	Detail
pGMoligo7189	Pre-made Human TRAF6/RNF85/MGC:3310 siRNA oligo Duplex	7189	Human	In-vitro grade; in-vivo grade	Detail
pGMoligo311245	Pre-made Rat Traf6 siRNA oligo Duplex	311245	Rat	In-vitro grade; in-vivo grade	Detail
pGMoligo22034	Pre-made Mouse Traf6/2310003F17Rik/C630032O20Rik siRNA oligo Duplex	22034	Mouse	In-vitro grade; in-vivo grade	Detail
pGMoligo716907	Pre-made Cynomolgus/Rhesus macaque TRAF6 siRNA oligo Duplex	716907	Cynomolgus/Rhesus macaque	In-vitro grade; in-vivo grade	Detail
pGMoligo101099750	Pre-made Cat/Feline TRAF6 siRNA oligo Duplex	101099750	Cat/Feline	In-vitro grade; in-vivo grade	Detail
pGMoligo100688110	Pre-made Dog/Canine TRAF6 siRNA oligo Duplex	100688110	Dog/Canine	In-vitro grade; in-vivo grade	Detail
pGMoligo539124	Pre-made Bovines/Cattle TRAF6 siRNA oligo Duplex	539124	Bovines/Cattle	In-vitro grade; in-vivo grade	Detail
pGMoligo100052296	Pre-made Equine/Horse TRAF6 siRNA oligo Duplex	100052296	Equine/Horse	In-vitro grade; in-vivo grade	Detail

TRAF6 antibody/GMab

Cat No.	Species	Antibody Name	Format	Classified by tag	Detail
GM-Tg-hg-T15051-Ab	Human	Anti-Human TRAF6 monoclonal antibody	mab	Therapeutics Target antibody, Cytokine antibody	Detail
GM-Tg-rg-T15051-Ab	Rat	Anti-Rat TRAF6 monoclonal antibody	mab	Therapeutics Target antibody, Cytokine antibody	Detail
GM-Tg-mg-T15051-Ab	Mouse	Anti-Mouse TRAF6 monoclonal antibody	mab	Therapeutics Target antibody, Cytokine antibody	Detail
GM-Tg-cynog-T15051-Ab	Cynomolgus/Rhesus macaque	Anti-Cynomolgus/Rhesus macaque TRAF6 monoclonal antibody	mab	Therapeutics Target antibody, Cytokine antibody	Detail
GM-Tg-felg-T15051-Ab	Cat/Feline	Anti-Cat/Feline TRAF6 monoclonal antibody	mab	Therapeutics Target antibody, Cytokine antibody	Detail
GM-Tg-cang-T15051-Ab	Dog/Canine	Anti-Dog/Canine TRAF6 monoclonal antibody	mab	Therapeutics Target antibody, Cytokine antibody	Detail
GM-Tg-bovg-T15051-Ab	Bovines/Cattle	Anti-Bovines/Cattle TRAF6 monoclonal antibody	mab	Therapeutics Target antibody, Cytokine antibody	Detail
GM-Tg-equg-T15051-Ab	Equine/Horse	Anti-Equine/Horse TRAF6 monoclonal antibody	mab	Therapeutics Target antibody, Cytokine antibody	Detail

TRAF6 recombinant protein

Cat No.	Species	Antigen Name	Expression Platform	Detail
GM-Tg-hg-T15051-Ag	Human	Human TRAF6 recombinant protein	Mammalian cell	Detail
GM-Tg-rg-T15051-Ag	Rat	Rat TRAF6 recombinant protein	Mammalian cell	Detail
GM-Tg-mg-T15051-Ag	Mouse	Mouse TRAF6 recombinant protein	Mammalian cell	Detail
GM-Tg-cynog-T15051-Ag	Cynomolgus/Rhesus macaque	Cynomolgus/Rhesus macaque TRAF6 recombinant protein	Mammalian cell	Detail
GM-Tg-felg-T15051-Ag	Cat/Feline	Cat/Feline TRAF6 recombinant protein	Mammalian cell	Detail
GM-Tg-cang-T15051-Ag	Dog/Canine	Dog/Canine TRAF6 recombinant protein	Mammalian cell	Detail
GM-Tg-bovg-T15051-Ag	Bovines/Cattle	Bovines/Cattle TRAF6 recombinant protein	Mammalian cell	Detail
GM-Tg-equg-T15051-Ag	Equine/Horse	Equine/Horse TRAF6 recombinant protein	Mammalian cell	Detail