Recombinant multi-species SHP2/PTPN11 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SHP2/PTPN11 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]
The Alternative Names of target: SHP2, PTPN11,Tyrosine-protein phosphatase non-receptor type 11,Protein-tyrosine phosphatase 1D (PTP-1D), Protein-tyrosine phosphatase 2C (PTP-2C), SH-PTP2 (SHP-2, Shp2), SH-PTP3,CFC,NS1,JMML,SHP2,BPTP3,PTP2C,METCDS,PTP-1D,SH-PTP2,SH-PTP3

Target products collectionGo to SHP2/PTPN11 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T13057-Ab-1/ GM-Tg-hg-T13057-Ab-2 Human SHP2/PTPN11 protein Human
GM-Tg-rg-T13057-Ab-1/ GM-Tg-rg-T13057-Ab-2 Rat SHP2/PTPN11 protein Rat
GM-Tg-mg-T13057-Ab-1/ GM-Tg-mg-T13057-Ab-2 Mouse SHP2/PTPN11 protein Mouse
GM-Tg-cynog-T13057-Ab-1/ GM-Tg-cynog-T13057-Ab-2 Cynomolgus/Rhesus macaque SHP2/PTPN11 monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T13057-Ab-1/ GM-Tg-felg-T13057-Ab-2 Feline SHP2/PTPN11 protein Feline
GM-Tg-cang-T13057-Ab-1/ GM-Tg-cang-T13057-Ab-2 Canine SHP2/PTPN11 protein Canine
GM-Tg-bovg-T13057-Ab-1/ GM-Tg-bovg-T13057-Ab-2 Bovine SHP2/PTPN11 protein Bovine
GM-Tg-equg-T13057-Ab-1/ GM-Tg-equg-T13057-Ab-2 Equine SHP2/PTPN11 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T13057-Ab-1/ GM-Tg-hg-T13057-Ab-2; GM-Tg-rg-T13057-Ab-1/ GM-Tg-rg-T13057-Ab-2;
GM-Tg-mg-T13057-Ab-1/ GM-Tg-mg-T13057-Ab-2; GM-Tg-cynog-T13057-Ab-1/ GM-Tg-cynog-T13057-Ab-2;
GM-Tg-felg-T13057-Ab-1/ GM-Tg-felg-T13057-Ab-2; GM-Tg-cang-T13057-Ab-1/ GM-Tg-cang-T13057-Ab-2;
GM-Tg-bovg-T13057-Ab-1/ GM-Tg-bovg-T13057-Ab-2; GM-Tg-equg-T13057-Ab-1/ GM-Tg-equg-T13057-Ab-2
Products Name SHP2/PTPN11 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name SHP2/PTPN11
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SHP2/PTPN11 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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