SHP2/PTPN11 Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore SHP2/PTPN11 gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Introcelluar Protein.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]

Target ID GM-T13057
Target Name SHP2/PTPN11
Gene Group ldentifer
(Target Gene ID in Homo species)
5781
Gene ID 100056857 (Equus caballus), 101085500 (Felis catus), 19247 (Mus musculus), 25622 (Rattus norvegicus)
477488 (Canis lupus familiaris), 533590 (Bos taurus), 5781 (Homo sapiens), 712044 (Macaca mulatta)
Target Alternative Names PTPN11,Ptpn11,Syp,Shp2,PTP1D,PTP2C,SAP-2,SHP-2,SH-PTP2,SH-PTP3,2700084A17Rik,SHP2,CFC,NS1,JMML,BPTP3,METCDS,PTP-1D
Uniprot Accession P35235,P41499,Q06124
Uniprot Entry Name
Protein Sub-location Introcelluar Protein
Category Therapeutics Target
Disease cancer, Breast Cancer
Disease from KEGG Ras signaling pathway, Phospholipase D signaling pathway, Axon guidance, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Leukocyte transendothelial migration, Neurotrophin signaling pathway, Adipocytokine signaling pathway, Insulin resistance, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Proteoglycans in cancer, Renal cell carcinoma, Chronic myeloid leukemia, PD-L1 expression and PD-1 checkpoint pathway in cancer
Gene Ensembl ENSECAG00000024560, ENSMUSG00000043733, ENSCAFG00845021271, ENSBTAG00000002048, ENSG00000179295, ENSMMUG00000013253
Target Classification Kinase, Pathway


Pre-made viral vector of SHP2/PTPN11 cDNA Clones/ORF Plasmid

Cat No.Product NameNMIDGeneIDSpeciesTypeMarkerFusion TagPromoterDetail
pGMLV000276Human PTPN11/BPTP3/CFC Lentivirus plasmidNM_0028345781HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
pGMLV002132Human PTPN11/BPTP3/CFC Lentivirus plasmidNM_002834.55781HumanLentivirus plasmidZsGreen6xHis (C-Terminal)CMVDetail
pGMLV002452Human PTPN11/BPTP3/CFC Lentivirus plasmidNM_002834.55781HumanLentivirus plasmidZsGreen3xflag (C-Terminal)EF1Detail
pGMAD000149Human PTPN11/BPTP3/CFC Adenovirus plasmidNM_0028345781HumanAdenovirus plasmidGFP3xflag (C-Terminal)EF1Detail
pGMPC001341Human PTPN11/BPTP3/CFC Mammalian (Non-Viral Vector) plasmidNM_0028345781HumanMammalian (Non-Viral Vector) plasmidNullMYC (C-Terminal)CMVDetail
vGMLV000276Human PTPN11/BPTP3/CFC Lentivirus particleNM_0028345781HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
vGMLV002132Human PTPN11/BPTP3/CFC Lentivirus particleNM_002834.55781HumanLentivirus particleZsGreen6xHis (C-Terminal)CMVDetail
vGMLV002452Human PTPN11/BPTP3/CFC Lentivirus particleNM_002834.55781HumanLentivirus particleZsGreen3xflag (C-Terminal)EF1Detail
vGMAD000149Human PTPN11/BPTP3/CFC Adenovirus particleNM_0028345781HumanAdenovirus particleGFP3xflag (C-Terminal)EF1Detail


SHP2/PTPN11 siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.Product NameGeneIDSpeciesGradeDetail
pGMoligo5781Pre-made Human PTPN11/CFC/NS1 siRNA oligo Duplex5781HumanIn-vitro grade; in-vivo gradeDetail
pGMoligo25622Pre-made Rat Ptpn11/Shp2 siRNA oligo Duplex25622RatIn-vitro grade; in-vivo gradeDetail
pGMoligo19247Pre-made Mouse Ptpn11/Syp/Shp2 siRNA oligo Duplex19247MouseIn-vitro grade; in-vivo gradeDetail
pGMoligo712044Pre-made Cynomolgus/Rhesus macaque PTPN11/SHP2 siRNA oligo Duplex712044Cynomolgus/Rhesus macaqueIn-vitro grade; in-vivo gradeDetail
pGMoligo101085500Pre-made Cat/Feline PTPN11 siRNA oligo Duplex101085500Cat/FelineIn-vitro grade; in-vivo gradeDetail
pGMoligo477488Pre-made Dog/Canine PTPN11/SHP-2 siRNA oligo Duplex477488Dog/CanineIn-vitro grade; in-vivo gradeDetail
pGMoligo533590Pre-made Bovines/Cattle PTPN11/SHP2 siRNA oligo Duplex533590Bovines/CattleIn-vitro grade; in-vivo gradeDetail
pGMoligo100056857Pre-made Equine/Horse PTPN11 siRNA oligo Duplex100056857Equine/HorseIn-vitro grade; in-vivo gradeDetail


SHP2/PTPN11 antibody/GMab

Cat No.SpeciesAntibody NameFormatClassified by tagDetail
GM-Tg-hg-T13057-AbHumanAnti-Human SHP2/PTPN11 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-rg-T13057-AbRatAnti-Rat SHP2/PTPN11 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-mg-T13057-AbMouseAnti-Mouse SHP2/PTPN11 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-cynog-T13057-AbCynomolgus/Rhesus macaqueAnti-Cynomolgus/Rhesus macaque SHP2/PTPN11 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-felg-T13057-AbCat/FelineAnti-Cat/Feline SHP2/PTPN11 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-cang-T13057-AbDog/CanineAnti-Dog/Canine SHP2/PTPN11 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-bovg-T13057-AbBovines/CattleAnti-Bovines/Cattle SHP2/PTPN11 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-equg-T13057-AbEquine/HorseAnti-Equine/Horse SHP2/PTPN11 monoclonal antibodymabTherapeutics Target antibodyDetail


SHP2/PTPN11 recombinant protein

Cat No.SpeciesAntigen NameExpression PlatformDetail
GM-Tg-hg-T13057-AgHumanHuman SHP2/PTPN11 recombinant proteinMammalian cellDetail
GM-Tg-rg-T13057-AgRatRat SHP2/PTPN11 recombinant proteinMammalian cellDetail
GM-Tg-mg-T13057-AgMouseMouse SHP2/PTPN11 recombinant proteinMammalian cellDetail
GM-Tg-cynog-T13057-AgCynomolgus/Rhesus macaqueCynomolgus/Rhesus macaque SHP2/PTPN11 recombinant proteinMammalian cellDetail
GM-Tg-felg-T13057-AgCat/FelineCat/Feline SHP2/PTPN11 recombinant proteinMammalian cellDetail
GM-Tg-cang-T13057-AgDog/CanineDog/Canine SHP2/PTPN11 recombinant proteinMammalian cellDetail
GM-Tg-bovg-T13057-AgBovines/CattleBovines/Cattle SHP2/PTPN11 recombinant proteinMammalian cellDetail
GM-Tg-equg-T13057-AgEquine/HorseEquine/Horse SHP2/PTPN11 recombinant proteinMammalian cellDetail