Explore SHP2/PTPN11 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]
Target ID |
GM-T13057
|
Target Name |
SHP2/PTPN11
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5781
|
Gene ID |
100056857 (Equus caballus), 101085500 (Felis catus), 19247 (Mus musculus), 25622 (Rattus norvegicus) 477488 (Canis lupus familiaris), 533590 (Bos taurus), 5781 (Homo sapiens), 712044 (Macaca mulatta)
|
Target Alternative Names |
PTPN11,Ptpn11,Syp,Shp2,PTP1D,PTP2C,SAP-2,SHP-2,SH-PTP2,SH-PTP3,2700084A17Rik,SHP2,CFC,NS1,JMML,BPTP3,METCDS,PTP-1D
|
Uniprot Accession |
P35235,P41499,Q06124
|
Uniprot Entry Name |
|
Protein Sub-location |
Introcelluar Protein
|
Category |
Therapeutics Target
|
Disease |
cancer, Breast Cancer
|
Disease from KEGG |
Ras signaling pathway, Phospholipase D signaling pathway, Axon guidance, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Leukocyte transendothelial migration, Neurotrophin signaling pathway, Adipocytokine signaling pathway, Insulin resistance, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Proteoglycans in cancer, Renal cell carcinoma, Chronic myeloid leukemia, PD-L1 expression and PD-1 checkpoint pathway in cancer
|
Gene Ensembl |
ENSECAG00000024560, ENSMUSG00000043733, ENSCAFG00845021271, ENSBTAG00000002048, ENSG00000179295, ENSMMUG00000013253
|
Target Classification |
Kinase, Pathway
|
Pre-made viral vector of SHP2/PTPN11 cDNA Clones/ORF Plasmid
SHP2/PTPN11 siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo5781 | Pre-made Human PTPN11/CFC/NS1 siRNA oligo Duplex | 5781 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo25622 | Pre-made Rat Ptpn11/Shp2 siRNA oligo Duplex | 25622 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo19247 | Pre-made Mouse Ptpn11/Syp/Shp2 siRNA oligo Duplex | 19247 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo712044 | Pre-made Cynomolgus/Rhesus macaque PTPN11/SHP2 siRNA oligo Duplex | 712044 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo101085500 | Pre-made Cat/Feline PTPN11 siRNA oligo Duplex | 101085500 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo477488 | Pre-made Dog/Canine PTPN11/SHP-2 siRNA oligo Duplex | 477488 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo533590 | Pre-made Bovines/Cattle PTPN11/SHP2 siRNA oligo Duplex | 533590 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100056857 | Pre-made Equine/Horse PTPN11 siRNA oligo Duplex | 100056857 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
SHP2/PTPN11 antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T13057-Ab | Human | Anti-Human SHP2/PTPN11 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-rg-T13057-Ab | Rat | Anti-Rat SHP2/PTPN11 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-mg-T13057-Ab | Mouse | Anti-Mouse SHP2/PTPN11 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-cynog-T13057-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SHP2/PTPN11 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-felg-T13057-Ab | Cat/Feline | Anti-Cat/Feline SHP2/PTPN11 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-cang-T13057-Ab | Dog/Canine | Anti-Dog/Canine SHP2/PTPN11 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-bovg-T13057-Ab | Bovines/Cattle | Anti-Bovines/Cattle SHP2/PTPN11 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-equg-T13057-Ab | Equine/Horse | Anti-Equine/Horse SHP2/PTPN11 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
SHP2/PTPN11 recombinant protein
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T13057-Ag | Human | Human SHP2/PTPN11 recombinant protein | Mammalian cell | Detail |
GM-Tg-rg-T13057-Ag | Rat | Rat SHP2/PTPN11 recombinant protein | Mammalian cell | Detail |
GM-Tg-mg-T13057-Ag | Mouse | Mouse SHP2/PTPN11 recombinant protein | Mammalian cell | Detail |
GM-Tg-cynog-T13057-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SHP2/PTPN11 recombinant protein | Mammalian cell | Detail |
GM-Tg-felg-T13057-Ag | Cat/Feline | Cat/Feline SHP2/PTPN11 recombinant protein | Mammalian cell | Detail |
GM-Tg-cang-T13057-Ag | Dog/Canine | Dog/Canine SHP2/PTPN11 recombinant protein | Mammalian cell | Detail |
GM-Tg-bovg-T13057-Ag | Bovines/Cattle | Bovines/Cattle SHP2/PTPN11 recombinant protein | Mammalian cell | Detail |
GM-Tg-equg-T13057-Ag | Equine/Horse | Equine/Horse SHP2/PTPN11 recombinant protein | Mammalian cell | Detail |