Recombinant multi-species LCK protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine LCK protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016]
The Alternative Names of target: Hck-3,IMD22,LCK,LSK,Lck,Lck1,Lcktkr,Leukocyte C-terminal Src kinase (LSK),Lsk,Lskt,Lymphocyte cell-specific protein-tyrosine kinase,Protein YT16,Proto-oncogene Lck,T cell-specific protein-tyrosine kinase,Tyrosine-protein kinase Lck,YT16,p56-LCK,p56,p56Lck,p56lck,pp58lck

Target products collectionGo to LCK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T12499-Ag-1/ GM-Tg-hg-T12499-Ag-2 Human LCK protein Human
GM-Tg-rg-T12499-Ag-1/ GM-Tg-rg-T12499-Ag-2 Rat LCK protein Rat
GM-Tg-mg-T12499-Ag-1/ GM-Tg-mg-T12499-Ag-2 Mouse LCK protein Mouse
GM-Tg-cynog-T12499-Ag-1/ GM-Tg-cynog-T12499-Ag-2 Cynomolgus/Rhesus macaque LCK protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T12499-Ag-1/ GM-Tg-felg-T12499-Ag-2 Feline LCK protein Feline
GM-Tg-cang-T12499-Ag-1/ GM-Tg-cang-T12499-Ag-2 Canine LCK protein Canine
GM-Tg-bovg-T12499-Ag-1/ GM-Tg-bovg-T12499-Ag-2 Bovine LCK protein Bovine
GM-Tg-equg-T12499-Ag-1/ GM-Tg-equg-T12499-Ag-2 Equine LCK protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T12499-Ag-1/ GM-Tg-hg-T12499-Ag-2; GM-Tg-rg-T12499-Ag-1/ GM-Tg-rg-T12499-Ag-2;
GM-Tg-mg-T12499-Ag-1/ GM-Tg-mg-T12499-Ag-2; GM-Tg-cynog-T12499-Ag-1/ GM-Tg-cynog-T12499-Ag-2;
GM-Tg-felg-T12499-Ag-1/ GM-Tg-felg-T12499-Ag-2; GM-Tg-cang-T12499-Ag-1/ GM-Tg-cang-T12499-Ag-2;
GM-Tg-bovg-T12499-Ag-1/ GM-Tg-bovg-T12499-Ag-2; GM-Tg-equg-T12499-Ag-1/ GM-Tg-equg-T12499-Ag-2
Products Name LCK protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name LCK
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine LCK protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.