LCK Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore LCK gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Introcelluar Protein.
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016]

Target ID GM-T12499
Target Name LCK
Gene Group ldentifer
（Target Gene ID in Homo species) 		3932
Gene ID 100146139 (Equus caballus), 101098805 (Felis catus), 16818 (Mus musculus), 313050 (Rattus norvegicus)
3932 (Homo sapiens), 478151 (Canis lupus familiaris), 508890 (Bos taurus), 717704 (Macaca mulatta)
Target Alternative Names Hck-3,IMD22,LCK,LSK,Lck,Lck1,Lcktkr,Leukocyte C-terminal Src kinase (LSK),Lsk,Lskt,Lymphocyte cell-specific protein-tyrosine kinase,Protein YT16,Proto-oncogene Lck,T cell-specific protein-tyrosine kinase,Tyrosine-protein kinase Lck,YT16,p56-LCK,p56,p56Lck,p56lck,pp58lck
Uniprot Accession P06240,Q01621,P06239
Protein Sub-location Introcelluar Protein
Category Therapeutics Target
Disease cancer
Disease from KEGG NF-kappa B signaling pathway, Osteoclast differentiation, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Yersinia infection, Human T-cell leukemia virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer
Gene Ensembl ENSECAG00000023256, ENSMUSG00000000409, ENSG00000182866, ENSCAFG00845004976, ENSBTAG00000012695, ENSMMUG00000040694
Target Classification Kinase, Tumor-associated antigen (TAA)


Pre-made viral vector of LCK cDNA Clones/ORF Plasmid

Cat No.Product NameNMIDGeneIDSpeciesTypeMarkerFusion TagPromoterDetail
pGMLP005345Human LCK/IMD22/LSK Lentivirus plasmidNM_001042771.23932HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
pGMLV001401Human LCK/IMD22/LSK Lentivirus plasmidNM_0053563932HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
vGMLP005345Human LCK/IMD22/LSK Lentivirus particleNM_001042771.23932HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
vGMLV001401Human LCK/IMD22/LSK Lentivirus particleNM_0053563932HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
pGMPC000497Rat Lck/Lck1/Lcktkr Mammalian (Non-Viral Vector) plasmidNM_001100709.1313050RatMammalian (Non-Viral Vector) plasmidNull3xflag (C-Terminal)CMVDetail
pGMLPm005214Mouse Lck/Hck-3/Lsk Lentivirus plasmidNM_001162432.116818MouseLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
vGMLPm005214Mouse Lck/Hck-3/Lsk Lentivirus particleNM_001162432.116818MouseLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail


LCK siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.Product NameGeneIDSpeciesGradeDetail
pGMoligo3932Pre-made Human LCK/LSK/YT16 siRNA oligo Duplex3932HumanIn-vitro grade; in-vivo gradeDetail
pGMoligo313050Pre-made Rat Lck/Lck1/Lcktkr siRNA oligo Duplex313050RatIn-vitro grade; in-vivo gradeDetail
pGMoligo16818Pre-made Mouse Lck/Lsk/Lskt siRNA oligo Duplex16818MouseIn-vitro grade; in-vivo gradeDetail
pGMoligo717704Pre-made Cynomolgus/Rhesus macaque LCK siRNA oligo Duplex717704Cynomolgus/Rhesus macaqueIn-vitro grade; in-vivo gradeDetail
pGMoligo101098805Pre-made Cat/Feline LCK siRNA oligo Duplex101098805Cat/FelineIn-vitro grade; in-vivo gradeDetail
pGMoligo478151Pre-made Dog/Canine LCK siRNA oligo Duplex478151Dog/CanineIn-vitro grade; in-vivo gradeDetail
pGMoligo508890Pre-made Bovines/Cattle LCK siRNA oligo Duplex508890Bovines/CattleIn-vitro grade; in-vivo gradeDetail
pGMoligo100146139Pre-made Equine/Horse LCK siRNA oligo Duplex100146139Equine/HorseIn-vitro grade; in-vivo gradeDetail


LCK antibody/GMab

Cat No.SpeciesAntibody NameFormatClassified by tagDetail
GM-Tg-hg-T12499-AbHumanAnti-Human LCK monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-rg-T12499-AbRatAnti-Rat LCK monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-mg-T12499-AbMouseAnti-Mouse LCK monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-cynog-T12499-AbCynomolgus/Rhesus macaqueAnti-Cynomolgus/Rhesus macaque LCK monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-felg-T12499-AbCat/FelineAnti-Cat/Feline LCK monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-cang-T12499-AbDog/CanineAnti-Dog/Canine LCK monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-bovg-T12499-AbBovines/CattleAnti-Bovines/Cattle LCK monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-equg-T12499-AbEquine/HorseAnti-Equine/Horse LCK monoclonal antibodymabTherapeutics Target antibodyDetail


LCK recombinant protein

Cat No.SpeciesAntigen NameExpression PlatformDetail
GM-Tg-hg-T12499-AgHumanHuman LCK recombinant proteinMammalian cellDetail
GM-Tg-rg-T12499-AgRatRat LCK recombinant proteinMammalian cellDetail
GM-Tg-mg-T12499-AgMouseMouse LCK recombinant proteinMammalian cellDetail
GM-Tg-cynog-T12499-AgCynomolgus/Rhesus macaqueCynomolgus/Rhesus macaque LCK recombinant proteinMammalian cellDetail
GM-Tg-felg-T12499-AgCat/FelineCat/Feline LCK recombinant proteinMammalian cellDetail
GM-Tg-cang-T12499-AgDog/CanineDog/Canine LCK recombinant proteinMammalian cellDetail
GM-Tg-bovg-T12499-AgBovines/CattleBovines/Cattle LCK recombinant proteinMammalian cellDetail
GM-Tg-equg-T12499-AgEquine/HorseEquine/Horse LCK recombinant proteinMammalian cellDetail