Recombinant multi-species Cyclin D1/CCND1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Cyclin D1/CCND1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019]
The Alternative Names of target: B-cell lymphoma 1 protein (BCL-1),BCL-1 oncogene,BCL1,CCND1,Ccnd1,CycD1,Cyclin D1,Cyl-1,D11S287E,G1/S-specific cyclin-D1,PRAD1,PRAD1 oncogene,U21B31,bcl-1,cD1

Target products collectionGo to Cyclin D1/CCND1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T12355-Ag-1/ GM-Tg-hg-T12355-Ag-2 Human Cyclin D1/CCND1 protein Human
GM-Tg-rg-T12355-Ag-1/ GM-Tg-rg-T12355-Ag-2 Rat Cyclin D1/CCND1 protein Rat
GM-Tg-mg-T12355-Ag-1/ GM-Tg-mg-T12355-Ag-2 Mouse Cyclin D1/CCND1 protein Mouse
GM-Tg-cynog-T12355-Ag-1/ GM-Tg-cynog-T12355-Ag-2 Cynomolgus/Rhesus macaque Cyclin D1/CCND1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T12355-Ag-1/ GM-Tg-felg-T12355-Ag-2 Feline Cyclin D1/CCND1 protein Feline
GM-Tg-cang-T12355-Ag-1/ GM-Tg-cang-T12355-Ag-2 Canine Cyclin D1/CCND1 protein Canine
GM-Tg-bovg-T12355-Ag-1/ GM-Tg-bovg-T12355-Ag-2 Bovine Cyclin D1/CCND1 protein Bovine
GM-Tg-equg-T12355-Ag-1/ GM-Tg-equg-T12355-Ag-2 Equine Cyclin D1/CCND1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T12355-Ag-1/ GM-Tg-hg-T12355-Ag-2; GM-Tg-rg-T12355-Ag-1/ GM-Tg-rg-T12355-Ag-2;
GM-Tg-mg-T12355-Ag-1/ GM-Tg-mg-T12355-Ag-2; GM-Tg-cynog-T12355-Ag-1/ GM-Tg-cynog-T12355-Ag-2;
GM-Tg-felg-T12355-Ag-1/ GM-Tg-felg-T12355-Ag-2; GM-Tg-cang-T12355-Ag-1/ GM-Tg-cang-T12355-Ag-2;
GM-Tg-bovg-T12355-Ag-1/ GM-Tg-bovg-T12355-Ag-2; GM-Tg-equg-T12355-Ag-1/ GM-Tg-equg-T12355-Ag-2
Products Name Cyclin D1/CCND1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Cyclin D1/CCND1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Cyclin D1/CCND1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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