Recombinant multi-species androgen receptor/AR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine androgen receptor/AR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
The Alternative Names of target: AIS,AR,AR8,Andr,Androgen receptor,Ar,DHTR,Dihydrotestosterone receptor,HUMARA,HYSP1,KD,NR3C4,Nuclear receptor subfamily 3 group C member 4,SBMA,SMAX1,TFM,Tfm,androgen receptor

Target products collectionGo to androgen receptor/AR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T11211-Ag-1/ GM-Tg-hg-T11211-Ag-2 Human androgen receptor/AR protein Human
GM-Tg-rg-T11211-Ag-1/ GM-Tg-rg-T11211-Ag-2 Rat androgen receptor/AR protein Rat
GM-Tg-mg-T11211-Ag-1/ GM-Tg-mg-T11211-Ag-2 Mouse androgen receptor/AR protein Mouse
GM-Tg-cynog-T11211-Ag-1/ GM-Tg-cynog-T11211-Ag-2 Cynomolgus/Rhesus macaque androgen receptor/AR protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T11211-Ag-1/ GM-Tg-felg-T11211-Ag-2 Feline androgen receptor/AR protein Feline
GM-Tg-cang-T11211-Ag-1/ GM-Tg-cang-T11211-Ag-2 Canine androgen receptor/AR protein Canine
GM-Tg-bovg-T11211-Ag-1/ GM-Tg-bovg-T11211-Ag-2 Bovine androgen receptor/AR protein Bovine
GM-Tg-equg-T11211-Ag-1/ GM-Tg-equg-T11211-Ag-2 Equine androgen receptor/AR protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T11211-Ag-1/ GM-Tg-hg-T11211-Ag-2; GM-Tg-rg-T11211-Ag-1/ GM-Tg-rg-T11211-Ag-2;
GM-Tg-mg-T11211-Ag-1/ GM-Tg-mg-T11211-Ag-2; GM-Tg-cynog-T11211-Ag-1/ GM-Tg-cynog-T11211-Ag-2;
GM-Tg-felg-T11211-Ag-1/ GM-Tg-felg-T11211-Ag-2; GM-Tg-cang-T11211-Ag-1/ GM-Tg-cang-T11211-Ag-2;
GM-Tg-bovg-T11211-Ag-1/ GM-Tg-bovg-T11211-Ag-2; GM-Tg-equg-T11211-Ag-1/ GM-Tg-equg-T11211-Ag-2
Products Name androgen receptor/AR protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name androgen receptor/AR
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine androgen receptor/AR protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.