Explore androgen receptor/AR gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
Target ID |
GM-T11211
|
Target Name |
androgen receptor/AR
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
367
|
Gene ID |
100033980 (Equus caballus), 101081787 (Felis catus), 11835 (Mus musculus), 24208 (Rattus norvegicus) 280675 (Bos taurus), 367 (Homo sapiens), 403588 (Canis lupus familiaris), 574293 (Macaca mulatta)
|
Target Alternative Names |
AIS,AR,AR8,Andr,Androgen receptor,Ar,DHTR,Dihydrotestosterone receptor,HUMARA,HYSP1,KD,NR3C4,Nuclear receptor subfamily 3 group C member 4,SBMA,SMAX1,TFM,Tfm,androgen receptor
|
Uniprot Accession |
P19091,P15207,P10275,Q9TT90,Q6QT55
|
Uniprot Entry Name |
|
Protein Sub-location |
Introcelluar Protein
|
Category |
Therapeutics Target, Immuno-oncology Target
|
Disease |
cancer, Prostatic neoplasms, Prostate cancer
|
Disease from KEGG |
Pathways in cancer, Chemical carcinogenesis - receptor activation, Prostate cancer
|
Gene Ensembl |
ENSECAG00000010160, ENSMUSG00000046532, ENSBTAG00000022255, ENSG00000169083, ENSCAFG00845028051, ENSMMUG00000011437
|
Target Classification |
Nuclear Receptors, Checkpoint-Immuno Oncology
|
Pre-made viral vector of androgen receptor/AR cDNA Clones/ORF Plasmid
androgen receptor/AR siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo367 | Pre-made Human AR/KD/AIS siRNA oligo Duplex | 367 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo24208 | Pre-made Rat Ar/Tfm/Andr siRNA oligo Duplex | 24208 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo11835 | Pre-made Mouse Ar/Tfm siRNA oligo Duplex | 11835 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo574293 | Pre-made Cynomolgus/Rhesus macaque AR siRNA oligo Duplex | 574293 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo101081787 | Pre-made Cat/Feline AR siRNA oligo Duplex | 101081787 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo403588 | Pre-made Dog/Canine AR siRNA oligo Duplex | 403588 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo280675 | Pre-made Bovines/Cattle AR siRNA oligo Duplex | 280675 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100033980 | Pre-made Equine/Horse AR siRNA oligo Duplex | 100033980 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
androgen receptor/AR antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T11211-Ab | Human | Anti-Human androgen receptor/AR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-rg-T11211-Ab | Rat | Anti-Rat androgen receptor/AR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-mg-T11211-Ab | Mouse | Anti-Mouse androgen receptor/AR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-cynog-T11211-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque androgen receptor/AR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-felg-T11211-Ab | Cat/Feline | Anti-Cat/Feline androgen receptor/AR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-cang-T11211-Ab | Dog/Canine | Anti-Dog/Canine androgen receptor/AR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-bovg-T11211-Ab | Bovines/Cattle | Anti-Bovines/Cattle androgen receptor/AR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-equg-T11211-Ab | Equine/Horse | Anti-Equine/Horse androgen receptor/AR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
androgen receptor/AR recombinant protein
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T11211-Ag | Human | Human androgen receptor/AR recombinant protein | Mammalian cell | Detail |
GM-Tg-rg-T11211-Ag | Rat | Rat androgen receptor/AR recombinant protein | Mammalian cell | Detail |
GM-Tg-mg-T11211-Ag | Mouse | Mouse androgen receptor/AR recombinant protein | Mammalian cell | Detail |
GM-Tg-cynog-T11211-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque androgen receptor/AR recombinant protein | Mammalian cell | Detail |
GM-Tg-felg-T11211-Ag | Cat/Feline | Cat/Feline androgen receptor/AR recombinant protein | Mammalian cell | Detail |
GM-Tg-cang-T11211-Ag | Dog/Canine | Dog/Canine androgen receptor/AR recombinant protein | Mammalian cell | Detail |
GM-Tg-bovg-T11211-Ag | Bovines/Cattle | Bovines/Cattle androgen receptor/AR recombinant protein | Mammalian cell | Detail |
GM-Tg-equg-T11211-Ag | Equine/Horse | Equine/Horse androgen receptor/AR recombinant protein | Mammalian cell | Detail |