Recombinant multi-species CDK8 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CDK8 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
The Alternative Names of target: CDK8,Cdk8,Cell division protein kinase 8,Cyclin-dependent kinase 8,IDDHBA,K35,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35,RGD1560888

Target products collectionGo to CDK8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T10822-Ag-1/ GM-Tg-hg-T10822-Ag-2 Human CDK8 protein Human
GM-Tg-rg-T10822-Ag-1/ GM-Tg-rg-T10822-Ag-2 Rat CDK8 protein Rat
GM-Tg-mg-T10822-Ag-1/ GM-Tg-mg-T10822-Ag-2 Mouse CDK8 protein Mouse
GM-Tg-cynog-T10822-Ag-1/ GM-Tg-cynog-T10822-Ag-2 Cynomolgus/Rhesus macaque CDK8 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T10822-Ag-1/ GM-Tg-felg-T10822-Ag-2 Feline CDK8 protein Feline
GM-Tg-cang-T10822-Ag-1/ GM-Tg-cang-T10822-Ag-2 Canine CDK8 protein Canine
GM-Tg-bovg-T10822-Ag-1/ GM-Tg-bovg-T10822-Ag-2 Bovine CDK8 protein Bovine
GM-Tg-equg-T10822-Ag-1/ GM-Tg-equg-T10822-Ag-2 Equine CDK8 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T10822-Ag-1/ GM-Tg-hg-T10822-Ag-2; GM-Tg-rg-T10822-Ag-1/ GM-Tg-rg-T10822-Ag-2;
GM-Tg-mg-T10822-Ag-1/ GM-Tg-mg-T10822-Ag-2; GM-Tg-cynog-T10822-Ag-1/ GM-Tg-cynog-T10822-Ag-2;
GM-Tg-felg-T10822-Ag-1/ GM-Tg-felg-T10822-Ag-2; GM-Tg-cang-T10822-Ag-1/ GM-Tg-cang-T10822-Ag-2;
GM-Tg-bovg-T10822-Ag-1/ GM-Tg-bovg-T10822-Ag-2; GM-Tg-equg-T10822-Ag-1/ GM-Tg-equg-T10822-Ag-2
Products Name CDK8 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CDK8
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CDK8 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.