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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
| Target ID |
GM-T10822
|
| Target Name |
CDK8
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
1024
|
| Gene ID |
100050819 (Equus caballus), 101086278 (Felis catus), 1024 (Homo sapiens), 264064 (Mus musculus) 486035 (Canis lupus familiaris), 498140 (Rattus norvegicus), 507149 (Bos taurus), 709761 (Macaca mulatta)
|
| Target Alternative Names |
CDK8,Cdk8,Cell division protein kinase 8,Cyclin-dependent kinase 8,IDDHBA,K35,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35,RGD1560888
|
| Uniprot Accession |
P49336,Q8R3L8
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Gene Ensembl |
ENSECAG00000015515, ENSG00000132964, ENSMUSG00000029635, ENSCAFG00845026285, ENSBTAG00000016737, ENSMMUG00000014841
|
Pre-made viral vector of CDK8 cDNA Clones/ORF Plasmid
CDK8 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1024 | Pre-made Human CDK8/K35/IDDHBA siRNA oligo Duplex | 1024 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo498140 | Pre-made Rat Cdk8/RGD1560888 siRNA oligo Duplex | 498140 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo264064 | Pre-made Mouse Cdk8 siRNA oligo Duplex | 264064 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo709761 | Pre-made Cynomolgus/Rhesus macaque CDK8 siRNA oligo Duplex | 709761 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101086278 | Pre-made Cat/Feline CDK8 siRNA oligo Duplex | 101086278 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo486035 | Pre-made Dog/Canine CDK8 siRNA oligo Duplex | 486035 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo507149 | Pre-made Bovines/Cattle CDK8 siRNA oligo Duplex | 507149 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100050819 | Pre-made Equine/Horse CDK8 siRNA oligo Duplex | 100050819 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CDK8 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T10822-Ab | Human | Anti-Human CDK8 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T10822-Ab | Rat | Anti-Rat CDK8 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T10822-Ab | Mouse | Anti-Mouse CDK8 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T10822-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CDK8 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T10822-Ab | Cat/Feline | Anti-Cat/Feline CDK8 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T10822-Ab | Dog/Canine | Anti-Dog/Canine CDK8 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T10822-Ab | Bovines/Cattle | Anti-Bovines/Cattle CDK8 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T10822-Ab | Equine/Horse | Anti-Equine/Horse CDK8 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
CDK8 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T10822-Ag | Human | Human CDK8 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T10822-Ag | Rat | Rat CDK8 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T10822-Ag | Mouse | Mouse CDK8 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T10822-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CDK8 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T10822-Ag | Cat/Feline | Cat/Feline CDK8 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T10822-Ag | Dog/Canine | Dog/Canine CDK8 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T10822-Ag | Bovines/Cattle | Bovines/Cattle CDK8 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T10822-Ag | Equine/Horse | Equine/Horse CDK8 recombinant protein | Mammalian cell | Detail |