Recombinant multi-species PDE5A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PDE5A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
The Alternative Names of target: 5'-cyclic phosphodiesterase,CGB-PDE,CN5A,Cgbpde,Cn5n,PDE5,PDE5A,PDE5A2,PDE5a2,Pde5,Pde5a,Pde5a1,cGMP-binding cGMP-specific phosphodiesterase (CGB-PDE),cGMP-specific 3'

Target products collectionGo to PDE5A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T07663-Ag-1/ GM-Tg-hg-T07663-Ag-2 Human PDE5A protein Human
GM-Tg-rg-T07663-Ag-1/ GM-Tg-rg-T07663-Ag-2 Rat PDE5A protein Rat
GM-Tg-mg-T07663-Ag-1/ GM-Tg-mg-T07663-Ag-2 Mouse PDE5A protein Mouse
GM-Tg-cynog-T07663-Ag-1/ GM-Tg-cynog-T07663-Ag-2 Cynomolgus/Rhesus macaque PDE5A protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T07663-Ag-1/ GM-Tg-felg-T07663-Ag-2 Feline PDE5A protein Feline
GM-Tg-cang-T07663-Ag-1/ GM-Tg-cang-T07663-Ag-2 Canine PDE5A protein Canine
GM-Tg-bovg-T07663-Ag-1/ GM-Tg-bovg-T07663-Ag-2 Bovine PDE5A protein Bovine
GM-Tg-equg-T07663-Ag-1/ GM-Tg-equg-T07663-Ag-2 Equine PDE5A protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T07663-Ag-1/ GM-Tg-hg-T07663-Ag-2; GM-Tg-rg-T07663-Ag-1/ GM-Tg-rg-T07663-Ag-2;
GM-Tg-mg-T07663-Ag-1/ GM-Tg-mg-T07663-Ag-2; GM-Tg-cynog-T07663-Ag-1/ GM-Tg-cynog-T07663-Ag-2;
GM-Tg-felg-T07663-Ag-1/ GM-Tg-felg-T07663-Ag-2; GM-Tg-cang-T07663-Ag-1/ GM-Tg-cang-T07663-Ag-2;
GM-Tg-bovg-T07663-Ag-1/ GM-Tg-bovg-T07663-Ag-2; GM-Tg-equg-T07663-Ag-1/ GM-Tg-equg-T07663-Ag-2
Products Name PDE5A protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name PDE5A
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PDE5A protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.