Explore PDE5A gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T07663
|
| Target Name |
PDE5A
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
8654
|
| Gene ID |
100072395 (Equus caballus), 100533976 (Felis catus), 171115 (Rattus norvegicus), 242202 (Mus musculus)
281972 (Bos taurus), 403825 (Canis lupus familiaris), 705592 (Macaca mulatta), 8654 (Homo sapiens)
|
| Target Alternative Names |
5'-cyclic phosphodiesterase,CGB-PDE,CN5A,Cgbpde,Cn5n,PDE5,PDE5A,PDE5A2,PDE5a2,Pde5,Pde5a,Pde5a1,cGMP-binding cGMP-specific phosphodiesterase (CGB-PDE),cGMP-specific 3'
|
| Uniprot Accession |
O54735,Q8CG03,Q28156,O77746,O76074
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
|
| Disease from KEGG |
Metabolic pathways, cGMP-PKG signaling pathway
|
| Gene Ensembl |
ENSECAG00000013957, ENSMUSG00000053965, ENSBTAG00000024888, ENSCAFG00845030199, ENSMMUG00000007305, ENSG00000138735
|
| Target Classification |
|
Pre-made viral vector of PDE5A cDNA Clones/ORF Plasmid
PDE5A siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8654 | Pre-made Human PDE5A/CN5A/PDE5 siRNA oligo Duplex | 8654 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo171115 | Pre-made Rat Pde5a/PDE5A2 siRNA oligo Duplex | 171115 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo242202 | Pre-made Mouse Pde5a/Cn5n/Pde5 siRNA oligo Duplex | 242202 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo705592 | Pre-made Cynomolgus/Rhesus macaque PDE5A siRNA oligo Duplex | 705592 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100533976 | Pre-made Cat/Feline PDE5A siRNA oligo Duplex | 100533976 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403825 | Pre-made Dog/Canine PDE5A/PDE5 siRNA oligo Duplex | 403825 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281972 | Pre-made Bovines/Cattle PDE5A siRNA oligo Duplex | 281972 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100072395 | Pre-made Equine/Horse PDE5A siRNA oligo Duplex | 100072395 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PDE5A antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T07663-Ab | Human | Anti-Human PDE5A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T07663-Ab | Rat | Anti-Rat PDE5A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T07663-Ab | Mouse | Anti-Mouse PDE5A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T07663-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PDE5A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T07663-Ab | Cat/Feline | Anti-Cat/Feline PDE5A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T07663-Ab | Dog/Canine | Anti-Dog/Canine PDE5A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T07663-Ab | Bovines/Cattle | Anti-Bovines/Cattle PDE5A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T07663-Ab | Equine/Horse | Anti-Equine/Horse PDE5A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
PDE5A recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T07663-Ag | Human | Human PDE5A recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T07663-Ag | Rat | Rat PDE5A recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T07663-Ag | Mouse | Mouse PDE5A recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T07663-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PDE5A recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T07663-Ag | Cat/Feline | Cat/Feline PDE5A recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T07663-Ag | Dog/Canine | Dog/Canine PDE5A recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T07663-Ag | Bovines/Cattle | Bovines/Cattle PDE5A recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T07663-Ag | Equine/Horse | Equine/Horse PDE5A recombinant protein | Mammalian cell | Detail |
