Recombinant multi-species 5 Lipoxygenase/ALOX5/5-LOX protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine 5 Lipoxygenase/ALOX5/5-LOX protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
The Alternative Names of target: 5 Lipoxygenase,5-LO,5-LOX,5-lipoxygenase),5LO,5LPG,5LX,ALOX5,Alox5,Arachidonate 5-lipoxygenase (5-LO,F730011J02,LOG5,LOX5A,Polyunsaturated fatty acid 5-lipoxygenase

Target products collectionGo to 5 Lipoxygenase/ALOX5/5-LOX products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T00140-Ag-1/ GM-Tg-hg-T00140-Ag-2 Human 5 Lipoxygenase/ALOX5/5-LOX protein Human
GM-Tg-rg-T00140-Ag-1/ GM-Tg-rg-T00140-Ag-2 Rat 5 Lipoxygenase/ALOX5/5-LOX protein Rat
GM-Tg-mg-T00140-Ag-1/ GM-Tg-mg-T00140-Ag-2 Mouse 5 Lipoxygenase/ALOX5/5-LOX protein Mouse
GM-Tg-cynog-T00140-Ag-1/ GM-Tg-cynog-T00140-Ag-2 Cynomolgus/Rhesus macaque 5 Lipoxygenase/ALOX5/5-LOX protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T00140-Ag-1/ GM-Tg-felg-T00140-Ag-2 Feline 5 Lipoxygenase/ALOX5/5-LOX protein Feline
GM-Tg-cang-T00140-Ag-1/ GM-Tg-cang-T00140-Ag-2 Canine 5 Lipoxygenase/ALOX5/5-LOX protein Canine
GM-Tg-bovg-T00140-Ag-1/ GM-Tg-bovg-T00140-Ag-2 Bovine 5 Lipoxygenase/ALOX5/5-LOX protein Bovine
GM-Tg-equg-T00140-Ag-1/ GM-Tg-equg-T00140-Ag-2 Equine 5 Lipoxygenase/ALOX5/5-LOX protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T00140-Ag-1/ GM-Tg-hg-T00140-Ag-2; GM-Tg-rg-T00140-Ag-1/ GM-Tg-rg-T00140-Ag-2;
GM-Tg-mg-T00140-Ag-1/ GM-Tg-mg-T00140-Ag-2; GM-Tg-cynog-T00140-Ag-1/ GM-Tg-cynog-T00140-Ag-2;
GM-Tg-felg-T00140-Ag-1/ GM-Tg-felg-T00140-Ag-2; GM-Tg-cang-T00140-Ag-1/ GM-Tg-cang-T00140-Ag-2;
GM-Tg-bovg-T00140-Ag-1/ GM-Tg-bovg-T00140-Ag-2; GM-Tg-equg-T00140-Ag-1/ GM-Tg-equg-T00140-Ag-2
Products Name 5 Lipoxygenase/ALOX5/5-LOX protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name 5 Lipoxygenase/ALOX5/5-LOX
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine 5 Lipoxygenase/ALOX5/5-LOX protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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