Recombinant multi-species AANAT protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine AANAT protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
The Alternative Names of target: AA-NAT,AANAT,Aanat,Aralkylamine N-acetyltransferase (AA-NAT),DSPS,Nat-2,Nat4,SNAT,Serotonin N-acetyltransferase,Serotonin acetylase,Snat

Target products collectionGo to AANAT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-SE1491-Ag-1/ GM-Tg-hg-SE1491-Ag-2 Human AANAT protein Human
GM-Tg-rg-SE1491-Ag-1/ GM-Tg-rg-SE1491-Ag-2 Rat AANAT protein Rat
GM-Tg-mg-SE1491-Ag-1/ GM-Tg-mg-SE1491-Ag-2 Mouse AANAT protein Mouse
GM-Tg-cynog-SE1491-Ag-1/ GM-Tg-cynog-SE1491-Ag-2 Cynomolgus/Rhesus macaque AANAT protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-SE1491-Ag-1/ GM-Tg-felg-SE1491-Ag-2 Feline AANAT protein Feline
GM-Tg-cang-SE1491-Ag-1/ GM-Tg-cang-SE1491-Ag-2 Canine AANAT protein Canine
GM-Tg-bovg-SE1491-Ag-1/ GM-Tg-bovg-SE1491-Ag-2 Bovine AANAT protein Bovine
GM-Tg-equg-SE1491-Ag-1/ GM-Tg-equg-SE1491-Ag-2 Equine AANAT protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-SE1491-Ag-1/ GM-Tg-hg-SE1491-Ag-2; GM-Tg-rg-SE1491-Ag-1/ GM-Tg-rg-SE1491-Ag-2;
GM-Tg-mg-SE1491-Ag-1/ GM-Tg-mg-SE1491-Ag-2; GM-Tg-cynog-SE1491-Ag-1/ GM-Tg-cynog-SE1491-Ag-2;
GM-Tg-felg-SE1491-Ag-1/ GM-Tg-felg-SE1491-Ag-2; GM-Tg-cang-SE1491-Ag-1/ GM-Tg-cang-SE1491-Ag-2;
GM-Tg-bovg-SE1491-Ag-1/ GM-Tg-bovg-SE1491-Ag-2; GM-Tg-equg-SE1491-Ag-1/ GM-Tg-equg-SE1491-Ag-2
Products Name AANAT protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name AANAT
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine AANAT protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.