Recombinant multi-species Thyroglobulin/TG protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Thyroglobulin/TG protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
The Alternative Names of target: AITD3,TG,TGN,Tg,Tgn,Thyroglobulin,cog

Target products collectionGo to Thyroglobulin/TG products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-SE1335-Ag-1/ GM-Tg-hg-SE1335-Ag-2 Human Thyroglobulin/TG protein Human
GM-Tg-rg-SE1335-Ag-1/ GM-Tg-rg-SE1335-Ag-2 Rat Thyroglobulin/TG protein Rat
GM-Tg-mg-SE1335-Ag-1/ GM-Tg-mg-SE1335-Ag-2 Mouse Thyroglobulin/TG protein Mouse
GM-Tg-cynog-SE1335-Ag-1/ GM-Tg-cynog-SE1335-Ag-2 Cynomolgus/Rhesus macaque Thyroglobulin/TG protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-SE1335-Ag-1/ GM-Tg-felg-SE1335-Ag-2 Feline Thyroglobulin/TG protein Feline
GM-Tg-cang-SE1335-Ag-1/ GM-Tg-cang-SE1335-Ag-2 Canine Thyroglobulin/TG protein Canine
GM-Tg-bovg-SE1335-Ag-1/ GM-Tg-bovg-SE1335-Ag-2 Bovine Thyroglobulin/TG protein Bovine
GM-Tg-equg-SE1335-Ag-1/ GM-Tg-equg-SE1335-Ag-2 Equine Thyroglobulin/TG protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-SE1335-Ag-1/ GM-Tg-hg-SE1335-Ag-2; GM-Tg-rg-SE1335-Ag-1/ GM-Tg-rg-SE1335-Ag-2;
GM-Tg-mg-SE1335-Ag-1/ GM-Tg-mg-SE1335-Ag-2; GM-Tg-cynog-SE1335-Ag-1/ GM-Tg-cynog-SE1335-Ag-2;
GM-Tg-felg-SE1335-Ag-1/ GM-Tg-felg-SE1335-Ag-2; GM-Tg-cang-SE1335-Ag-1/ GM-Tg-cang-SE1335-Ag-2;
GM-Tg-bovg-SE1335-Ag-1/ GM-Tg-bovg-SE1335-Ag-2; GM-Tg-equg-SE1335-Ag-1/ GM-Tg-equg-SE1335-Ag-2
Products Name Thyroglobulin/TG protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Thyroglobulin/TG
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Thyroglobulin/TG protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.