Recombinant multi-species SPINK5 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SPINK5 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may exhibit unique activities and specificities. These proteins may play a role in skin and hair morphogenesis, as well as anti-inflammatory and antimicrobial protection of mucous epithelia. Mutations in this gene may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. This gene is present in a gene cluster on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
The Alternative Names of target: 2310065D10Rik,LEKT1,LEKTI,LETK1,LETKI,Lympho-epithelial Kazal-type-related inhibitor (LEKTI),NETS,NS,SPINK5,Serine protease inhibitor Kazal-type 5,Spink5,VAKT1,VAKTI

Target products collectionGo to SPINK5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-SE1312-Ag-1/ GM-Tg-hg-SE1312-Ag-2 Human SPINK5 protein Human
GM-Tg-rg-SE1312-Ag-1/ GM-Tg-rg-SE1312-Ag-2 Rat SPINK5 protein Rat
GM-Tg-mg-SE1312-Ag-1/ GM-Tg-mg-SE1312-Ag-2 Mouse SPINK5 protein Mouse
GM-Tg-cynog-SE1312-Ag-1/ GM-Tg-cynog-SE1312-Ag-2 Cynomolgus/Rhesus macaque SPINK5 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-SE1312-Ag-1/ GM-Tg-felg-SE1312-Ag-2 Feline SPINK5 protein Feline
GM-Tg-cang-SE1312-Ag-1/ GM-Tg-cang-SE1312-Ag-2 Canine SPINK5 protein Canine
GM-Tg-bovg-SE1312-Ag-1/ GM-Tg-bovg-SE1312-Ag-2 Bovine SPINK5 protein Bovine
GM-Tg-equg-SE1312-Ag-1/ GM-Tg-equg-SE1312-Ag-2 Equine SPINK5 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-SE1312-Ag-1/ GM-Tg-hg-SE1312-Ag-2; GM-Tg-rg-SE1312-Ag-1/ GM-Tg-rg-SE1312-Ag-2;
GM-Tg-mg-SE1312-Ag-1/ GM-Tg-mg-SE1312-Ag-2; GM-Tg-cynog-SE1312-Ag-1/ GM-Tg-cynog-SE1312-Ag-2;
GM-Tg-felg-SE1312-Ag-1/ GM-Tg-felg-SE1312-Ag-2; GM-Tg-cang-SE1312-Ag-1/ GM-Tg-cang-SE1312-Ag-2;
GM-Tg-bovg-SE1312-Ag-1/ GM-Tg-bovg-SE1312-Ag-2; GM-Tg-equg-SE1312-Ag-1/ GM-Tg-equg-SE1312-Ag-2
Products Name SPINK5 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name SPINK5
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SPINK5 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.