Recombinant multi-species PAPPA protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PAPPA protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]
The Alternative Names of target: 8430414N03Rik,ASBABP2,DIPLA1,IGFBP-4ase,IGFBP-4ase),Insulin-like growth factor-dependent IGF-binding protein 4 protease (IGF-dependent IGFBP-4 protease,PAG1,PAPA,PAPP-A,PAPPA,PAPPA1,Pappa,Pappa1,Pappalysin-1,Pregnancy-associated plasma protein A (PAPP-A)

Target products collectionGo to PAPPA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-SE1169-Ag-1/ GM-Tg-hg-SE1169-Ag-2 Human PAPPA protein Human
GM-Tg-rg-SE1169-Ag-1/ GM-Tg-rg-SE1169-Ag-2 Rat PAPPA protein Rat
GM-Tg-mg-SE1169-Ag-1/ GM-Tg-mg-SE1169-Ag-2 Mouse PAPPA protein Mouse
GM-Tg-cynog-SE1169-Ag-1/ GM-Tg-cynog-SE1169-Ag-2 Cynomolgus/Rhesus macaque PAPPA protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-SE1169-Ag-1/ GM-Tg-felg-SE1169-Ag-2 Feline PAPPA protein Feline
GM-Tg-cang-SE1169-Ag-1/ GM-Tg-cang-SE1169-Ag-2 Canine PAPPA protein Canine
GM-Tg-bovg-SE1169-Ag-1/ GM-Tg-bovg-SE1169-Ag-2 Bovine PAPPA protein Bovine
GM-Tg-equg-SE1169-Ag-1/ GM-Tg-equg-SE1169-Ag-2 Equine PAPPA protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-SE1169-Ag-1/ GM-Tg-hg-SE1169-Ag-2; GM-Tg-rg-SE1169-Ag-1/ GM-Tg-rg-SE1169-Ag-2;
GM-Tg-mg-SE1169-Ag-1/ GM-Tg-mg-SE1169-Ag-2; GM-Tg-cynog-SE1169-Ag-1/ GM-Tg-cynog-SE1169-Ag-2;
GM-Tg-felg-SE1169-Ag-1/ GM-Tg-felg-SE1169-Ag-2; GM-Tg-cang-SE1169-Ag-1/ GM-Tg-cang-SE1169-Ag-2;
GM-Tg-bovg-SE1169-Ag-1/ GM-Tg-bovg-SE1169-Ag-2; GM-Tg-equg-SE1169-Ag-1/ GM-Tg-equg-SE1169-Ag-2
Products Name PAPPA protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name PAPPA
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PAPPA protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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