Explore PAPPA gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]
| Target ID |
GM-SE1169
|
| Target Name |
PAPPA
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5069
|
| Gene ID |
100033920 (Equus caballus), 101089154 (Felis catus), 18491 (Mus musculus), 282647 (Bos taurus)
313262 (Rattus norvegicus), 481692 (Canis lupus familiaris), 5069 (Homo sapiens), 706783 (Macaca mulatta)
|
| Target Alternative Names |
8430414N03Rik,ASBABP2,DIPLA1,IGFBP-4ase,IGFBP-4ase),Insulin-like growth factor-dependent IGF-binding protein 4 protease (IGF-dependent IGFBP-4 protease,PAG1,PAPA,PAPP-A,PAPPA,PAPPA1,Pappa,Pappa1,Pappalysin-1,Pregnancy-associated plasma protein A (PAPP-A)
|
| Uniprot Accession |
Q8R4K8,Q13219
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Disease |
cancer
|
| Gene Ensembl |
ENSECAG00000023026, ENSMUSG00000028370, ENSBTAG00000004010, ENSCAFG00845011656, ENSG00000182752, ENSMMUG00000013099
|
| Target Classification |
Tumor-associated antigen (TAA)
|
PAPPA siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5069 | Pre-made Human PAPPA/PAPA/DIPLA1 siRNA oligo Duplex | 5069 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo313262 | Pre-made Rat Pappa/Pappa1 siRNA oligo Duplex | 313262 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18491 | Pre-made Mouse Pappa/PAG1/PAPP-A siRNA oligo Duplex | 18491 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo706783 | Pre-made Cynomolgus/Rhesus macaque PAPPA siRNA oligo Duplex | 706783 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101089154 | Pre-made Cat/Feline PAPPA siRNA oligo Duplex | 101089154 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo481692 | Pre-made Dog/Canine PAPPA siRNA oligo Duplex | 481692 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282647 | Pre-made Bovines/Cattle PAPPA siRNA oligo Duplex | 282647 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100033920 | Pre-made Equine/Horse PAPPA/PAPP-A siRNA oligo Duplex | 100033920 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PAPPA antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-SE1169-Ab | Human | Anti-Human PAPPA monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-SE1169-Ab | Rat | Anti-Rat PAPPA monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-SE1169-Ab | Mouse | Anti-Mouse PAPPA monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-SE1169-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PAPPA monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-SE1169-Ab | Cat/Feline | Anti-Cat/Feline PAPPA monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-SE1169-Ab | Dog/Canine | Anti-Dog/Canine PAPPA monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-SE1169-Ab | Bovines/Cattle | Anti-Bovines/Cattle PAPPA monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-SE1169-Ab | Equine/Horse | Anti-Equine/Horse PAPPA monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
PAPPA recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-SE1169-Ag | Human | Human PAPPA recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-SE1169-Ag | Rat | Rat PAPPA recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-SE1169-Ag | Mouse | Mouse PAPPA recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-SE1169-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PAPPA recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-SE1169-Ag | Cat/Feline | Cat/Feline PAPPA recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-SE1169-Ag | Dog/Canine | Dog/Canine PAPPA recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-SE1169-Ag | Bovines/Cattle | Bovines/Cattle PAPPA recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-SE1169-Ag | Equine/Horse | Equine/Horse PAPPA recombinant protein | Mammalian cell | Detail |
