Recombinant multi-species IL-18BP/IL18BP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-18BP/IL18BP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
The Alternative Names of target: FVH,IL-18BP,IL18BP,IL18BPa,Igifbp,Il18bp,Interleukin-18-binding protein,MC54L,Tadekinig-alfa

Target products collectionGo to IL-18BP/IL18BP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-SE1023-Ag-1/ GM-Tg-hg-SE1023-Ag-2 Human IL-18BP/IL18BP protein Human
GM-Tg-rg-SE1023-Ag-1/ GM-Tg-rg-SE1023-Ag-2 Rat IL-18BP/IL18BP protein Rat
GM-Tg-mg-SE1023-Ag-1/ GM-Tg-mg-SE1023-Ag-2 Mouse IL-18BP/IL18BP protein Mouse
GM-Tg-cynog-SE1023-Ag-1/ GM-Tg-cynog-SE1023-Ag-2 Cynomolgus/Rhesus macaque IL-18BP/IL18BP protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-SE1023-Ag-1/ GM-Tg-felg-SE1023-Ag-2 Feline IL-18BP/IL18BP protein Feline
GM-Tg-cang-SE1023-Ag-1/ GM-Tg-cang-SE1023-Ag-2 Canine IL-18BP/IL18BP protein Canine
GM-Tg-bovg-SE1023-Ag-1/ GM-Tg-bovg-SE1023-Ag-2 Bovine IL-18BP/IL18BP protein Bovine
GM-Tg-equg-SE1023-Ag-1/ GM-Tg-equg-SE1023-Ag-2 Equine IL-18BP/IL18BP protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-SE1023-Ag-1/ GM-Tg-hg-SE1023-Ag-2; GM-Tg-rg-SE1023-Ag-1/ GM-Tg-rg-SE1023-Ag-2;
GM-Tg-mg-SE1023-Ag-1/ GM-Tg-mg-SE1023-Ag-2; GM-Tg-cynog-SE1023-Ag-1/ GM-Tg-cynog-SE1023-Ag-2;
GM-Tg-felg-SE1023-Ag-1/ GM-Tg-felg-SE1023-Ag-2; GM-Tg-cang-SE1023-Ag-1/ GM-Tg-cang-SE1023-Ag-2;
GM-Tg-bovg-SE1023-Ag-1/ GM-Tg-bovg-SE1023-Ag-2; GM-Tg-equg-SE1023-Ag-1/ GM-Tg-equg-SE1023-Ag-2
Products Name IL-18BP/IL18BP protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name IL-18BP/IL18BP
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-18BP/IL18BP protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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