Recombinant multi-species HEXB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HEXB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
The Alternative Names of target: Beta-N-acetylhexosaminidase subunit beta (Hexosaminidase subunit B),Beta-hexosaminidase subunit beta,Cervical cancer proto-oncogene 7 protein (HCC-7),ENC-1AS,HEL-248,HEL-S-111,HEXB,Hexb,N-acetyl-beta-glucosaminidase subunit beta

Target products collectionGo to HEXB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-SE0260-Ag-1/ GM-Tg-hg-SE0260-Ag-2 Human HEXB protein Human
GM-Tg-rg-SE0260-Ag-1/ GM-Tg-rg-SE0260-Ag-2 Rat HEXB protein Rat
GM-Tg-mg-SE0260-Ag-1/ GM-Tg-mg-SE0260-Ag-2 Mouse HEXB protein Mouse
GM-Tg-cynog-SE0260-Ag-1/ GM-Tg-cynog-SE0260-Ag-2 Cynomolgus/Rhesus macaque HEXB protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-SE0260-Ag-1/ GM-Tg-felg-SE0260-Ag-2 Feline HEXB protein Feline
GM-Tg-cang-SE0260-Ag-1/ GM-Tg-cang-SE0260-Ag-2 Canine HEXB protein Canine
GM-Tg-bovg-SE0260-Ag-1/ GM-Tg-bovg-SE0260-Ag-2 Bovine HEXB protein Bovine
GM-Tg-equg-SE0260-Ag-1/ GM-Tg-equg-SE0260-Ag-2 Equine HEXB protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-SE0260-Ag-1/ GM-Tg-hg-SE0260-Ag-2; GM-Tg-rg-SE0260-Ag-1/ GM-Tg-rg-SE0260-Ag-2;
GM-Tg-mg-SE0260-Ag-1/ GM-Tg-mg-SE0260-Ag-2; GM-Tg-cynog-SE0260-Ag-1/ GM-Tg-cynog-SE0260-Ag-2;
GM-Tg-felg-SE0260-Ag-1/ GM-Tg-felg-SE0260-Ag-2; GM-Tg-cang-SE0260-Ag-1/ GM-Tg-cang-SE0260-Ag-2;
GM-Tg-bovg-SE0260-Ag-1/ GM-Tg-bovg-SE0260-Ag-2; GM-Tg-equg-SE0260-Ag-1/ GM-Tg-equg-SE0260-Ag-2
Products Name HEXB protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name HEXB
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HEXB protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.