Recombinant multi-species Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
The Alternative Names of target: Alpha-2-Macroglobulin, Alpha 2 Macroglobulin, A2M,Alpha-2-macroglobulin,Alpha-2-M,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5,A2MD,CPAMD5,FWP007,S863-7

Target products collectionGo to Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-SE0001-Ab-1/ GM-Tg-hg-SE0001-Ab-2 Human Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M protein Human
GM-Tg-rg-SE0001-Ab-1/ GM-Tg-rg-SE0001-Ab-2 Rat Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M protein Rat
GM-Tg-mg-SE0001-Ab-1/ GM-Tg-mg-SE0001-Ab-2 Mouse Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M protein Mouse
GM-Tg-cynog-SE0001-Ab-1/ GM-Tg-cynog-SE0001-Ab-2 Cynomolgus/Rhesus macaque Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-SE0001-Ab-1/ GM-Tg-felg-SE0001-Ab-2 Feline Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M protein Feline
GM-Tg-cang-SE0001-Ab-1/ GM-Tg-cang-SE0001-Ab-2 Canine Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M protein Canine
GM-Tg-bovg-SE0001-Ab-1/ GM-Tg-bovg-SE0001-Ab-2 Bovine Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M protein Bovine
GM-Tg-equg-SE0001-Ab-1/ GM-Tg-equg-SE0001-Ab-2 Equine Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-SE0001-Ab-1/ GM-Tg-hg-SE0001-Ab-2; GM-Tg-rg-SE0001-Ab-1/ GM-Tg-rg-SE0001-Ab-2;
GM-Tg-mg-SE0001-Ab-1/ GM-Tg-mg-SE0001-Ab-2; GM-Tg-cynog-SE0001-Ab-1/ GM-Tg-cynog-SE0001-Ab-2;
GM-Tg-felg-SE0001-Ab-1/ GM-Tg-felg-SE0001-Ab-2; GM-Tg-cang-SE0001-Ab-1/ GM-Tg-cang-SE0001-Ab-2;
GM-Tg-bovg-SE0001-Ab-1/ GM-Tg-bovg-SE0001-Ab-2; GM-Tg-equg-SE0001-Ab-1/ GM-Tg-equg-SE0001-Ab-2
Products Name Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.