Explore Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Secreted Protein/Potential Cytokines.
The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
| Target ID |
GM-SE0001
|
| Target Name |
Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2
|
| Gene ID |
101080460 (Felis catus), 2 (Homo sapiens), 24153 (Rattus norvegicus), 513856 (Bos taurus)
|
| Target Alternative Names |
A2M,A2m,A2MD,CPAMD5,FWP007,S863-7,Mam,A2m1,A2mb,A2maa,A2MAC1
|
| Uniprot Accession |
P01023,P06238,Q7SIH1
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Cytokine Target
|
| Disease |
prostate cancer, Malignant neoplasm of bladder, Nephrotic syndrome
|
| Disease from KEGG |
Complement and coagulation cascades
|
| Gene Ensembl |
ENSG00000175899, ENSBTAG00000018137
|
| Target Classification |
|
Pre-made viral vector of Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M cDNA Clones/ORF Plasmid
Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2 | Pre-made Human A2M/A2MD/CPAMD5 siRNA oligo Duplex | 2 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24153 | Pre-made Rat A2m/Mam/A2m1 siRNA oligo Duplex | 24153 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101080460 | Pre-made Cat/Feline A2M siRNA oligo Duplex | 101080460 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo513856 | Pre-made Bovines/Cattle A2M siRNA oligo Duplex | 513856 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-SE0001-Ab | Human | Anti-Human Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-rg-SE0001-Ab | Rat | Anti-Rat Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-felg-SE0001-Ab | Cat/Feline | Anti-Cat/Feline Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-SE0001-Ab | Bovines/Cattle | Anti-Bovines/Cattle Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-SE0001-Ag | Human | Human Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-SE0001-Ag | Rat | Rat Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-SE0001-Ag | Cat/Feline | Cat/Feline Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-SE0001-Ag | Bovines/Cattle | Bovines/Cattle Alpha-2-Macroglobulin/Alpha 2 Macroglobulin/A2M recombinant protein | Mammalian cell | Detail |
