Recombinant multi-species MAGEL2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MAGEL2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS. [provided by RefSeq, Oct 2010]
The Alternative Names of target: MAGE-like protein 2,MAGEL2,Mage-l2,Magel2,NDNL1,Necdin-like protein 1,PWLS,Protein nM15,SHFYNG,nM15,ns7

Target products collectionGo to MAGEL2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP9753-Ag-1/ GM-Tg-hg-IP9753-Ag-2 Human MAGEL2 protein Human
GM-Tg-rg-IP9753-Ag-1/ GM-Tg-rg-IP9753-Ag-2 Rat MAGEL2 protein Rat
GM-Tg-mg-IP9753-Ag-1/ GM-Tg-mg-IP9753-Ag-2 Mouse MAGEL2 protein Mouse
GM-Tg-cynog-IP9753-Ag-1/ GM-Tg-cynog-IP9753-Ag-2 Cynomolgus/Rhesus macaque MAGEL2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP9753-Ag-1/ GM-Tg-felg-IP9753-Ag-2 Feline MAGEL2 protein Feline
GM-Tg-cang-IP9753-Ag-1/ GM-Tg-cang-IP9753-Ag-2 Canine MAGEL2 protein Canine
GM-Tg-bovg-IP9753-Ag-1/ GM-Tg-bovg-IP9753-Ag-2 Bovine MAGEL2 protein Bovine
GM-Tg-equg-IP9753-Ag-1/ GM-Tg-equg-IP9753-Ag-2 Equine MAGEL2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP9753-Ag-1/ GM-Tg-hg-IP9753-Ag-2; GM-Tg-rg-IP9753-Ag-1/ GM-Tg-rg-IP9753-Ag-2;
GM-Tg-mg-IP9753-Ag-1/ GM-Tg-mg-IP9753-Ag-2; GM-Tg-cynog-IP9753-Ag-1/ GM-Tg-cynog-IP9753-Ag-2;
GM-Tg-felg-IP9753-Ag-1/ GM-Tg-felg-IP9753-Ag-2; GM-Tg-cang-IP9753-Ag-1/ GM-Tg-cang-IP9753-Ag-2;
GM-Tg-bovg-IP9753-Ag-1/ GM-Tg-bovg-IP9753-Ag-2; GM-Tg-equg-IP9753-Ag-1/ GM-Tg-equg-IP9753-Ag-2
Products Name MAGEL2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name MAGEL2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MAGEL2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.