Recombinant multi-species ARNT/HIF-1 beta/HIF1B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ARNT/HIF-1 beta/HIF1B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
The Alternative Names of target: ARNT,ARNT protein,ARNT1,Arnt,Arnt1,Aryl hydrocarbon receptor nuclear translocator,Class E basic helix-loop-helix protein 2 (bHLHe2),D3Ertd557e,Dioxin receptor,Drnt,ESTM42,HIF-1 beta,HIF-1-beta,HIF-1beta,HIF1-beta,HIF1-beta),HIF1B,HIF1BETA,Hif1b,Hypoxia-inducible factor 1-beta (HIF-1-beta,TANGO,bHLHe2,mKIAA4051,nuclear translocator

Target products collectionGo to ARNT/HIF-1 beta/HIF1B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP8766-Ag-1/ GM-Tg-hg-IP8766-Ag-2 Human ARNT/HIF-1 beta/HIF1B protein Human
GM-Tg-rg-IP8766-Ag-1/ GM-Tg-rg-IP8766-Ag-2 Rat ARNT/HIF-1 beta/HIF1B protein Rat
GM-Tg-mg-IP8766-Ag-1/ GM-Tg-mg-IP8766-Ag-2 Mouse ARNT/HIF-1 beta/HIF1B protein Mouse
GM-Tg-cynog-IP8766-Ag-1/ GM-Tg-cynog-IP8766-Ag-2 Cynomolgus/Rhesus macaque ARNT/HIF-1 beta/HIF1B protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP8766-Ag-1/ GM-Tg-felg-IP8766-Ag-2 Feline ARNT/HIF-1 beta/HIF1B protein Feline
GM-Tg-cang-IP8766-Ag-1/ GM-Tg-cang-IP8766-Ag-2 Canine ARNT/HIF-1 beta/HIF1B protein Canine
GM-Tg-bovg-IP8766-Ag-1/ GM-Tg-bovg-IP8766-Ag-2 Bovine ARNT/HIF-1 beta/HIF1B protein Bovine
GM-Tg-equg-IP8766-Ag-1/ GM-Tg-equg-IP8766-Ag-2 Equine ARNT/HIF-1 beta/HIF1B protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP8766-Ag-1/ GM-Tg-hg-IP8766-Ag-2; GM-Tg-rg-IP8766-Ag-1/ GM-Tg-rg-IP8766-Ag-2;
GM-Tg-mg-IP8766-Ag-1/ GM-Tg-mg-IP8766-Ag-2; GM-Tg-cynog-IP8766-Ag-1/ GM-Tg-cynog-IP8766-Ag-2;
GM-Tg-felg-IP8766-Ag-1/ GM-Tg-felg-IP8766-Ag-2; GM-Tg-cang-IP8766-Ag-1/ GM-Tg-cang-IP8766-Ag-2;
GM-Tg-bovg-IP8766-Ag-1/ GM-Tg-bovg-IP8766-Ag-2; GM-Tg-equg-IP8766-Ag-1/ GM-Tg-equg-IP8766-Ag-2
Products Name ARNT/HIF-1 beta/HIF1B protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ARNT/HIF-1 beta/HIF1B
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ARNT/HIF-1 beta/HIF1B protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.