Recombinant multi-species PHOX2A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PHOX2A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles. [provided by RefSeq, Jul 2008]
The Alternative Names of target: ARIX,ARIX1 homeodomain protein,Aristaless homeobox protein homolog,Arix,CFEOM2,FEOM2,NCAM2,PHOX2A,PMX2A,Paired mesoderm homeobox protein 2A,Paired-like homeobox 2A,Phox2,Phox2a,Pmx2,Pmx2a,Px2a

Target products collectionGo to PHOX2A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP8715-Ag-1/ GM-Tg-hg-IP8715-Ag-2 Human PHOX2A protein Human
GM-Tg-rg-IP8715-Ag-1/ GM-Tg-rg-IP8715-Ag-2 Rat PHOX2A protein Rat
GM-Tg-mg-IP8715-Ag-1/ GM-Tg-mg-IP8715-Ag-2 Mouse PHOX2A protein Mouse
GM-Tg-cynog-IP8715-Ag-1/ GM-Tg-cynog-IP8715-Ag-2 Cynomolgus/Rhesus macaque PHOX2A protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP8715-Ag-1/ GM-Tg-felg-IP8715-Ag-2 Feline PHOX2A protein Feline
GM-Tg-cang-IP8715-Ag-1/ GM-Tg-cang-IP8715-Ag-2 Canine PHOX2A protein Canine
GM-Tg-bovg-IP8715-Ag-1/ GM-Tg-bovg-IP8715-Ag-2 Bovine PHOX2A protein Bovine
GM-Tg-equg-IP8715-Ag-1/ GM-Tg-equg-IP8715-Ag-2 Equine PHOX2A protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP8715-Ag-1/ GM-Tg-hg-IP8715-Ag-2; GM-Tg-rg-IP8715-Ag-1/ GM-Tg-rg-IP8715-Ag-2;
GM-Tg-mg-IP8715-Ag-1/ GM-Tg-mg-IP8715-Ag-2; GM-Tg-cynog-IP8715-Ag-1/ GM-Tg-cynog-IP8715-Ag-2;
GM-Tg-felg-IP8715-Ag-1/ GM-Tg-felg-IP8715-Ag-2; GM-Tg-cang-IP8715-Ag-1/ GM-Tg-cang-IP8715-Ag-2;
GM-Tg-bovg-IP8715-Ag-1/ GM-Tg-bovg-IP8715-Ag-2; GM-Tg-equg-IP8715-Ag-1/ GM-Tg-equg-IP8715-Ag-2
Products Name PHOX2A protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name PHOX2A
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PHOX2A protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.