Recombinant multi-species Keratin 81/KRT81 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Keratin 81/KRT81 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. Some human genome assemblies (example T2T-CHM13) have a non-coding version of the gene due to the presence of a SNP that introduces a premature stop codon after codon 281. [provided by RefSeq, Jan 2024]
The Alternative Names of target: 1,HB1,Hair keratin K2.9,Hb-1,K81,KRT81,KRTHB1,Keratin,Keratin 81,Keratin-81 (K81),MLN137,Metastatic lymph node 137 gene protein (MLN 137),Type II hair keratin Hb1,Type-II keratin Kb21,basic,ghHKb1 (ghHb1),ghHkb1,hHAKB2-1,hair,type II cuticular Hb1

Target products collectionGo to Keratin 81/KRT81 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP8522-Ag-1/ GM-Tg-hg-IP8522-Ag-2 Human Keratin 81/KRT81 protein Human
GM-Tg-rg-IP8522-Ag-1/ GM-Tg-rg-IP8522-Ag-2 Rat Keratin 81/KRT81 protein Rat
GM-Tg-mg-IP8522-Ag-1/ GM-Tg-mg-IP8522-Ag-2 Mouse Keratin 81/KRT81 protein Mouse
GM-Tg-cynog-IP8522-Ag-1/ GM-Tg-cynog-IP8522-Ag-2 Cynomolgus/Rhesus macaque Keratin 81/KRT81 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP8522-Ag-1/ GM-Tg-felg-IP8522-Ag-2 Feline Keratin 81/KRT81 protein Feline
GM-Tg-cang-IP8522-Ag-1/ GM-Tg-cang-IP8522-Ag-2 Canine Keratin 81/KRT81 protein Canine
GM-Tg-bovg-IP8522-Ag-1/ GM-Tg-bovg-IP8522-Ag-2 Bovine Keratin 81/KRT81 protein Bovine
GM-Tg-equg-IP8522-Ag-1/ GM-Tg-equg-IP8522-Ag-2 Equine Keratin 81/KRT81 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP8522-Ag-1/ GM-Tg-hg-IP8522-Ag-2; GM-Tg-rg-IP8522-Ag-1/ GM-Tg-rg-IP8522-Ag-2;
GM-Tg-mg-IP8522-Ag-1/ GM-Tg-mg-IP8522-Ag-2; GM-Tg-cynog-IP8522-Ag-1/ GM-Tg-cynog-IP8522-Ag-2;
GM-Tg-felg-IP8522-Ag-1/ GM-Tg-felg-IP8522-Ag-2; GM-Tg-cang-IP8522-Ag-1/ GM-Tg-cang-IP8522-Ag-2;
GM-Tg-bovg-IP8522-Ag-1/ GM-Tg-bovg-IP8522-Ag-2; GM-Tg-equg-IP8522-Ag-1/ GM-Tg-equg-IP8522-Ag-2
Products Name Keratin 81/KRT81 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Keratin 81/KRT81
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Keratin 81/KRT81 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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