Recombinant multi-species APC protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine APC protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jun 2022]
The Alternative Names of target: APC,Adenomatous polyposis coli protein,Apc,BTPS2,CC1,DESMD,DP2,DP2.5,DP3,Deleted in polyposis 2.5,GS,Min,PPP1R46,Protein APC,RATAPC,mAPC

Target products collectionGo to APC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP8023-Ag-1/ GM-Tg-hg-IP8023-Ag-2 Human APC protein Human
GM-Tg-rg-IP8023-Ag-1/ GM-Tg-rg-IP8023-Ag-2 Rat APC protein Rat
GM-Tg-mg-IP8023-Ag-1/ GM-Tg-mg-IP8023-Ag-2 Mouse APC protein Mouse
GM-Tg-cynog-IP8023-Ag-1/ GM-Tg-cynog-IP8023-Ag-2 Cynomolgus/Rhesus macaque APC protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP8023-Ag-1/ GM-Tg-felg-IP8023-Ag-2 Feline APC protein Feline
GM-Tg-cang-IP8023-Ag-1/ GM-Tg-cang-IP8023-Ag-2 Canine APC protein Canine
GM-Tg-bovg-IP8023-Ag-1/ GM-Tg-bovg-IP8023-Ag-2 Bovine APC protein Bovine
GM-Tg-equg-IP8023-Ag-1/ GM-Tg-equg-IP8023-Ag-2 Equine APC protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP8023-Ag-1/ GM-Tg-hg-IP8023-Ag-2; GM-Tg-rg-IP8023-Ag-1/ GM-Tg-rg-IP8023-Ag-2;
GM-Tg-mg-IP8023-Ag-1/ GM-Tg-mg-IP8023-Ag-2; GM-Tg-cynog-IP8023-Ag-1/ GM-Tg-cynog-IP8023-Ag-2;
GM-Tg-felg-IP8023-Ag-1/ GM-Tg-felg-IP8023-Ag-2; GM-Tg-cang-IP8023-Ag-1/ GM-Tg-cang-IP8023-Ag-2;
GM-Tg-bovg-IP8023-Ag-1/ GM-Tg-bovg-IP8023-Ag-2; GM-Tg-equg-IP8023-Ag-1/ GM-Tg-equg-IP8023-Ag-2
Products Name APC protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name APC
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine APC protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.