Explore APC gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jun 2022]
| Target ID |
GM-IP8023
|
| Target Name |
APC
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
324
|
| Gene ID |
100064431 (Equus caballus), 101096138 (Felis catus), 11789 (Mus musculus), 24205 (Rattus norvegicus) 324 (Homo sapiens), 479139 (Canis lupus familiaris), 533233 (Bos taurus), 693443 (Macaca mulatta)
|
| Target Alternative Names |
APC,Adenomatous polyposis coli protein,Apc,BTPS2,CC1,DESMD,DP2,DP2.5,DP3,Deleted in polyposis 2.5,GS,Min,PPP1R46,Protein APC,RATAPC,mAPC
|
| Uniprot Accession |
Q61315,P70478,P25054
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Life Science Target
|
| Disease |
cancer, Colon cancer
|
| Gene Ensembl |
ENSECAG00000009003, ENSMUSG00000005871, ENSG00000134982, ENSCAFG00845003519, ENSBTAG00000018852, ENSMMUG00000000330
|
APC siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo324 | Pre-made Human APC/GS/DP2 siRNA oligo Duplex | 324 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24205 | Pre-made Rat Apc/RATAPC siRNA oligo Duplex | 24205 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11789 | Pre-made Mouse Apc/CC1/Min siRNA oligo Duplex | 11789 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo693443 | Pre-made Cynomolgus/Rhesus macaque APC siRNA oligo Duplex | 693443 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101096138 | Pre-made Cat/Feline APC siRNA oligo Duplex | 101096138 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo479139 | Pre-made Dog/Canine APC siRNA oligo Duplex | 479139 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo533233 | Pre-made Bovines/Cattle APC siRNA oligo Duplex | 533233 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100064431 | Pre-made Equine/Horse APC siRNA oligo Duplex | 100064431 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
APC antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP8023-Ab | Human | Anti-Human APC monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP8023-Ab | Rat | Anti-Rat APC monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP8023-Ab | Mouse | Anti-Mouse APC monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP8023-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque APC monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP8023-Ab | Cat/Feline | Anti-Cat/Feline APC monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP8023-Ab | Dog/Canine | Anti-Dog/Canine APC monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP8023-Ab | Bovines/Cattle | Anti-Bovines/Cattle APC monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP8023-Ab | Equine/Horse | Anti-Equine/Horse APC monoclonal antibody | mab | | Detail |
APC recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP8023-Ag | Human | Human APC recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP8023-Ag | Rat | Rat APC recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP8023-Ag | Mouse | Mouse APC recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP8023-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque APC recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP8023-Ag | Cat/Feline | Cat/Feline APC recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP8023-Ag | Dog/Canine | Dog/Canine APC recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP8023-Ag | Bovines/Cattle | Bovines/Cattle APC recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP8023-Ag | Equine/Horse | Equine/Horse APC recombinant protein | Mammalian cell | Detail |