Recombinant multi-species UHRF1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine UHRF1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]
The Alternative Names of target: Ac2-121,E3 ubiquitin-protein ligase UHRF1,ICBP90,Inverted CCAAT box-binding protein of 90 kDa,Np95,Nuclear protein 95,Nuclear zinc finger protein Np95 (HuNp95,RING finger protein 106,RING-type E3 ubiquitin transferase UHRF1,RNF106,TDRD22,Transcription factor ICBP90,UHRF1,Ubiquitin-like PHD and RING finger domain-containing protein 1 (hUHRF1),Ubiquitin-like-containing PHD and RING finger domains protein 1,Uhrf1,hNP95,hNp95),hUHRF1,huNp95

Target products collectionGo to UHRF1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP7797-Ag-1/ GM-Tg-hg-IP7797-Ag-2 Human UHRF1 protein Human
GM-Tg-rg-IP7797-Ag-1/ GM-Tg-rg-IP7797-Ag-2 Rat UHRF1 protein Rat
GM-Tg-mg-IP7797-Ag-1/ GM-Tg-mg-IP7797-Ag-2 Mouse UHRF1 protein Mouse
GM-Tg-cynog-IP7797-Ag-1/ GM-Tg-cynog-IP7797-Ag-2 Cynomolgus/Rhesus macaque UHRF1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP7797-Ag-1/ GM-Tg-felg-IP7797-Ag-2 Feline UHRF1 protein Feline
GM-Tg-cang-IP7797-Ag-1/ GM-Tg-cang-IP7797-Ag-2 Canine UHRF1 protein Canine
GM-Tg-bovg-IP7797-Ag-1/ GM-Tg-bovg-IP7797-Ag-2 Bovine UHRF1 protein Bovine
GM-Tg-equg-IP7797-Ag-1/ GM-Tg-equg-IP7797-Ag-2 Equine UHRF1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP7797-Ag-1/ GM-Tg-hg-IP7797-Ag-2; GM-Tg-rg-IP7797-Ag-1/ GM-Tg-rg-IP7797-Ag-2;
GM-Tg-mg-IP7797-Ag-1/ GM-Tg-mg-IP7797-Ag-2; GM-Tg-cynog-IP7797-Ag-1/ GM-Tg-cynog-IP7797-Ag-2;
GM-Tg-felg-IP7797-Ag-1/ GM-Tg-felg-IP7797-Ag-2; GM-Tg-cang-IP7797-Ag-1/ GM-Tg-cang-IP7797-Ag-2;
GM-Tg-bovg-IP7797-Ag-1/ GM-Tg-bovg-IP7797-Ag-2; GM-Tg-equg-IP7797-Ag-1/ GM-Tg-equg-IP7797-Ag-2
Products Name UHRF1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name UHRF1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine UHRF1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.