Recombinant multi-species NEDD4L protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NEDD4L protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
The Alternative Names of target: 1300012C07Rik,E3 ubiquitin-protein ligase NEDD4-like,HECT-type E3 ubiquitin transferase NED4L,NEDD4,NEDD4-2,NEDD4.2,NEDD4L,Nedd4-2,Nedd4b,Nedd4l,PVNH7,RSP5,hNEDD4-2

Target products collectionGo to NEDD4L products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP6833-Ag-1/ GM-Tg-hg-IP6833-Ag-2 Human NEDD4L protein Human
GM-Tg-rg-IP6833-Ag-1/ GM-Tg-rg-IP6833-Ag-2 Rat NEDD4L protein Rat
GM-Tg-mg-IP6833-Ag-1/ GM-Tg-mg-IP6833-Ag-2 Mouse NEDD4L protein Mouse
GM-Tg-cynog-IP6833-Ag-1/ GM-Tg-cynog-IP6833-Ag-2 Cynomolgus/Rhesus macaque NEDD4L protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP6833-Ag-1/ GM-Tg-felg-IP6833-Ag-2 Feline NEDD4L protein Feline
GM-Tg-cang-IP6833-Ag-1/ GM-Tg-cang-IP6833-Ag-2 Canine NEDD4L protein Canine
GM-Tg-bovg-IP6833-Ag-1/ GM-Tg-bovg-IP6833-Ag-2 Bovine NEDD4L protein Bovine
GM-Tg-equg-IP6833-Ag-1/ GM-Tg-equg-IP6833-Ag-2 Equine NEDD4L protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP6833-Ag-1/ GM-Tg-hg-IP6833-Ag-2; GM-Tg-rg-IP6833-Ag-1/ GM-Tg-rg-IP6833-Ag-2;
GM-Tg-mg-IP6833-Ag-1/ GM-Tg-mg-IP6833-Ag-2; GM-Tg-cynog-IP6833-Ag-1/ GM-Tg-cynog-IP6833-Ag-2;
GM-Tg-felg-IP6833-Ag-1/ GM-Tg-felg-IP6833-Ag-2; GM-Tg-cang-IP6833-Ag-1/ GM-Tg-cang-IP6833-Ag-2;
GM-Tg-bovg-IP6833-Ag-1/ GM-Tg-bovg-IP6833-Ag-2; GM-Tg-equg-IP6833-Ag-1/ GM-Tg-equg-IP6833-Ag-2
Products Name NEDD4L protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name NEDD4L
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NEDD4L protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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