Recombinant multi-species ALDOB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ALDOB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]
The Alternative Names of target: ALDB,ALDO2,ALDOB,Aldo-2,Aldo2,Aldob,Fructose-bisphosphate aldolase B,LIV10,Liver-type aldolase
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Product information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP6624-Ag-1/ GM-Tg-hg-IP6624-Ag-2 | Human ALDOB protein | Human |
| GM-Tg-rg-IP6624-Ag-1/ GM-Tg-rg-IP6624-Ag-2 | Rat ALDOB protein | Rat |
| GM-Tg-mg-IP6624-Ag-1/ GM-Tg-mg-IP6624-Ag-2 | Mouse ALDOB protein | Mouse |
| GM-Tg-cynog-IP6624-Ag-1/ GM-Tg-cynog-IP6624-Ag-2 | Cynomolgus/Rhesus macaque ALDOB protein | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP6624-Ag-1/ GM-Tg-felg-IP6624-Ag-2 | Feline ALDOB protein | Feline |
| GM-Tg-cang-IP6624-Ag-1/ GM-Tg-cang-IP6624-Ag-2 | Canine ALDOB protein | Canine |
| GM-Tg-bovg-IP6624-Ag-1/ GM-Tg-bovg-IP6624-Ag-2 | Bovine ALDOB protein | Bovine |
| GM-Tg-equg-IP6624-Ag-1/ GM-Tg-equg-IP6624-Ag-2 | Equine ALDOB protein | Equine |
Size: 1mg | 10mg | 100mg
Product Description
| Catalog No. |
GM-Tg-hg-IP6624-Ag-1/ GM-Tg-hg-IP6624-Ag-2;
GM-Tg-rg-IP6624-Ag-1/ GM-Tg-rg-IP6624-Ag-2;
GM-Tg-mg-IP6624-Ag-1/ GM-Tg-mg-IP6624-Ag-2; GM-Tg-cynog-IP6624-Ag-1/ GM-Tg-cynog-IP6624-Ag-2; GM-Tg-felg-IP6624-Ag-1/ GM-Tg-felg-IP6624-Ag-2; GM-Tg-cang-IP6624-Ag-1/ GM-Tg-cang-IP6624-Ag-2; GM-Tg-bovg-IP6624-Ag-1/ GM-Tg-bovg-IP6624-Ag-2; GM-Tg-equg-IP6624-Ag-1/ GM-Tg-equg-IP6624-Ag-2 |
| Products Name | ALDOB protein |
| Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
| Target Name | ALDOB |
| Protein Sub-location | Introcelluar Protein |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
| Tag | His |
| Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ALDOB protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution |
Lyophilized from GM's Protein Stability Buffer2
(PSB2,Confidential Ingredients) or PBS
(pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
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GMab, developed by GeneMedi, constitutes an
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strategic animal model systematization, in-depth
pharmacokinetic & pharmacodynamic
(PK/PD) modeling, and intricate mechanism of
action (MOA) investigations.