Recombinant multi-species CYP27B1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CYP27B1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I. [provided by RefSeq, Jul 2008]
The Alternative Names of target: 25-OHD-1 alpha-hydroxylase,25-hydroxyvitamin D(3) 1-alpha-hydroxylase (VD3 1A hydroxylase),25-hydroxyvitamin D-1 alpha hydroxylase,CP2B,CYP1,CYP1alpha,CYP27B,CYP27B1,Calcidiol 1-monooxygenase,Cp2b,Cyp1,Cyp27b,Cyp27b1,Cyp40,Cytochrome P450 subfamily XXVIIB polypeptide 1,Cytochrome P450C1 alpha,Cytochrome P450VD1-alpha,Cytochrome p450 27B1,P450c1,PDDR,Pddr,VDD1,VDDR,VDDRI,VDR,Vdd1,Vddr,VddrI,Vdr,mitochondrial

Target products collectionGo to CYP27B1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP6010-Ag-1/ GM-Tg-hg-IP6010-Ag-2 Human CYP27B1 protein Human
GM-Tg-rg-IP6010-Ag-1/ GM-Tg-rg-IP6010-Ag-2 Rat CYP27B1 protein Rat
GM-Tg-mg-IP6010-Ag-1/ GM-Tg-mg-IP6010-Ag-2 Mouse CYP27B1 protein Mouse
GM-Tg-cynog-IP6010-Ag-1/ GM-Tg-cynog-IP6010-Ag-2 Cynomolgus/Rhesus macaque CYP27B1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP6010-Ag-1/ GM-Tg-felg-IP6010-Ag-2 Feline CYP27B1 protein Feline
GM-Tg-cang-IP6010-Ag-1/ GM-Tg-cang-IP6010-Ag-2 Canine CYP27B1 protein Canine
GM-Tg-bovg-IP6010-Ag-1/ GM-Tg-bovg-IP6010-Ag-2 Bovine CYP27B1 protein Bovine
GM-Tg-equg-IP6010-Ag-1/ GM-Tg-equg-IP6010-Ag-2 Equine CYP27B1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP6010-Ag-1/ GM-Tg-hg-IP6010-Ag-2; GM-Tg-rg-IP6010-Ag-1/ GM-Tg-rg-IP6010-Ag-2;
GM-Tg-mg-IP6010-Ag-1/ GM-Tg-mg-IP6010-Ag-2; GM-Tg-cynog-IP6010-Ag-1/ GM-Tg-cynog-IP6010-Ag-2;
GM-Tg-felg-IP6010-Ag-1/ GM-Tg-felg-IP6010-Ag-2; GM-Tg-cang-IP6010-Ag-1/ GM-Tg-cang-IP6010-Ag-2;
GM-Tg-bovg-IP6010-Ag-1/ GM-Tg-bovg-IP6010-Ag-2; GM-Tg-equg-IP6010-Ag-1/ GM-Tg-equg-IP6010-Ag-2
Products Name CYP27B1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CYP27B1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CYP27B1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.