Explore CYP27B1 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I. [provided by RefSeq, Jul 2008]
| Target ID |
GM-IP6010
|
| Target Name |
CYP27B1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
1594
|
| Gene ID |
100034100 (Equus caballus), 100750221 (Felis catus), 114700 (Rattus norvegicus), 13115 (Mus musculus) 1594 (Homo sapiens), 481133 (Canis lupus familiaris), 539630 (Bos taurus), 715747 (Macaca mulatta)
|
| Target Alternative Names |
25-OHD-1 alpha-hydroxylase,25-hydroxyvitamin D(3) 1-alpha-hydroxylase (VD3 1A hydroxylase),25-hydroxyvitamin D-1 alpha hydroxylase,CP2B,CYP1,CYP1alpha,CYP27B,CYP27B1,Calcidiol 1-monooxygenase,Cp2b,Cyp1,Cyp27b,Cyp27b1,Cyp40,Cytochrome P450 subfamily XXVIIB polypeptide 1,Cytochrome P450C1 alpha,Cytochrome P450VD1-alpha,Cytochrome p450 27B1,P450c1,PDDR,Pddr,VDD1,VDDR,VDDRI,VDR,Vdd1,Vddr,VddrI,Vdr,mitochondrial
|
| Uniprot Accession |
O35132,O35084,O15528
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Life Science Target
|
| Disease |
cancer
|
| Gene Ensembl |
ENSECAG00000025143, ENSMUSG00000006724, ENSG00000111012, ENSCAFG00845013886, ENSBTAG00000016906, ENSMMUG00000022144
|
CYP27B1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1594 | Pre-made Human CYP27B1/VDR/CP2B siRNA oligo Duplex | 1594 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo114700 | Pre-made Rat Cyp27b1/Cyp40 siRNA oligo Duplex | 114700 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13115 | Pre-made Mouse Cyp27b1/Vdr/Cp2b siRNA oligo Duplex | 13115 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo715747 | Pre-made Cynomolgus/Rhesus macaque CYP27B1 siRNA oligo Duplex | 715747 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100750221 | Pre-made Cat/Feline CYP27B1 siRNA oligo Duplex | 100750221 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo481133 | Pre-made Dog/Canine CYP27B1 siRNA oligo Duplex | 481133 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo539630 | Pre-made Bovines/Cattle CYP27B1 siRNA oligo Duplex | 539630 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034100 | Pre-made Equine/Horse CYP27B1 siRNA oligo Duplex | 100034100 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CYP27B1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP6010-Ab | Human | Anti-Human CYP27B1 monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP6010-Ab | Rat | Anti-Rat CYP27B1 monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP6010-Ab | Mouse | Anti-Mouse CYP27B1 monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP6010-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CYP27B1 monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP6010-Ab | Cat/Feline | Anti-Cat/Feline CYP27B1 monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP6010-Ab | Dog/Canine | Anti-Dog/Canine CYP27B1 monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP6010-Ab | Bovines/Cattle | Anti-Bovines/Cattle CYP27B1 monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP6010-Ab | Equine/Horse | Anti-Equine/Horse CYP27B1 monoclonal antibody | mab | | Detail |
CYP27B1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP6010-Ag | Human | Human CYP27B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP6010-Ag | Rat | Rat CYP27B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP6010-Ag | Mouse | Mouse CYP27B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP6010-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CYP27B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP6010-Ag | Cat/Feline | Cat/Feline CYP27B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP6010-Ag | Dog/Canine | Dog/Canine CYP27B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP6010-Ag | Bovines/Cattle | Bovines/Cattle CYP27B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP6010-Ag | Equine/Horse | Equine/Horse CYP27B1 recombinant protein | Mammalian cell | Detail |