Recombinant multi-species SP140 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SP140 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]
The Alternative Names of target: LYSP100,LYSP100-A,LYSP100-B,Lymphoid-restricted homolog of Sp100 (LYSp100),Nuclear autoantigen Sp-140,Nuclear body protein SP140,SP140,SP140L,Speckled 140 kDa

Target products collectionGo to SP140 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP4082-Ag-1/ GM-Tg-hg-IP4082-Ag-2 Human SP140 protein Human
GM-Tg-rg-IP4082-Ag-1/ GM-Tg-rg-IP4082-Ag-2 Rat SP140 protein Rat
GM-Tg-mg-IP4082-Ag-1/ GM-Tg-mg-IP4082-Ag-2 Mouse SP140 protein Mouse
GM-Tg-cynog-IP4082-Ag-1/ GM-Tg-cynog-IP4082-Ag-2 Cynomolgus/Rhesus macaque SP140 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP4082-Ag-1/ GM-Tg-felg-IP4082-Ag-2 Feline SP140 protein Feline
GM-Tg-cang-IP4082-Ag-1/ GM-Tg-cang-IP4082-Ag-2 Canine SP140 protein Canine
GM-Tg-bovg-IP4082-Ag-1/ GM-Tg-bovg-IP4082-Ag-2 Bovine SP140 protein Bovine
GM-Tg-equg-IP4082-Ag-1/ GM-Tg-equg-IP4082-Ag-2 Equine SP140 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP4082-Ag-1/ GM-Tg-hg-IP4082-Ag-2; GM-Tg-rg-IP4082-Ag-1/ GM-Tg-rg-IP4082-Ag-2;
GM-Tg-mg-IP4082-Ag-1/ GM-Tg-mg-IP4082-Ag-2; GM-Tg-cynog-IP4082-Ag-1/ GM-Tg-cynog-IP4082-Ag-2;
GM-Tg-felg-IP4082-Ag-1/ GM-Tg-felg-IP4082-Ag-2; GM-Tg-cang-IP4082-Ag-1/ GM-Tg-cang-IP4082-Ag-2;
GM-Tg-bovg-IP4082-Ag-1/ GM-Tg-bovg-IP4082-Ag-2; GM-Tg-equg-IP4082-Ag-1/ GM-Tg-equg-IP4082-Ag-2
Products Name SP140 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name SP140
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SP140 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.