Explore SP140 gene products and cross-species
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]
| Target ID |
GM-IP4082
|
| Target Name |
SP140
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
11262
|
| Gene ID |
11262 (Homo sapiens), 609988 (Canis lupus familiaris), 710925 (Macaca mulatta)
|
| Target Alternative Names |
LYSP100,LYSP100-A,LYSP100-B,Lymphoid-restricted homolog of Sp100 (LYSp100),Nuclear autoantigen Sp-140,Nuclear body protein SP140,SP140,SP140L,Speckled 140 kDa
|
| Uniprot Accession |
Q13342
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Life Science Target
|
| Gene Ensembl |
ENSG00000079263, ENSCAFG00845020520, ENSMMUG00000012199
|
SP140 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo11262 | Pre-made Human SP140/LYSP100/LYSP100-A siRNA oligo Duplex | 11262 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo710925 | Pre-made Cynomolgus/Rhesus macaque SP140 siRNA oligo Duplex | 710925 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo609988 | Pre-made Dog/Canine SP140/SP140L siRNA oligo Duplex | 609988 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
SP140 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP4082-Ab | Human | Anti-Human SP140 monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP4082-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SP140 monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP4082-Ab | Dog/Canine | Anti-Dog/Canine SP140 monoclonal antibody | mab | | Detail |
SP140 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP4082-Ag | Human | Human SP140 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP4082-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SP140 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP4082-Ag | Dog/Canine | Dog/Canine SP140 recombinant protein | Mammalian cell | Detail |
