Recombinant multi-species HBG2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HBG2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
The Alternative Names of target: Gamma-2-globin,HBG-T1,HBG2,Hb F Ggamma,Hemoglobin gamma-2 chain,Hemoglobin gamma-G chain,Hemoglobin subunit gamma-2,TNCY

Target products collectionGo to HBG2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP2887-Ag-1/ GM-Tg-hg-IP2887-Ag-2 Human HBG2 protein Human
GM-Tg-rg-IP2887-Ag-1/ GM-Tg-rg-IP2887-Ag-2 Rat HBG2 protein Rat
GM-Tg-mg-IP2887-Ag-1/ GM-Tg-mg-IP2887-Ag-2 Mouse HBG2 protein Mouse
GM-Tg-cynog-IP2887-Ag-1/ GM-Tg-cynog-IP2887-Ag-2 Cynomolgus/Rhesus macaque HBG2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP2887-Ag-1/ GM-Tg-felg-IP2887-Ag-2 Feline HBG2 protein Feline
GM-Tg-cang-IP2887-Ag-1/ GM-Tg-cang-IP2887-Ag-2 Canine HBG2 protein Canine
GM-Tg-bovg-IP2887-Ag-1/ GM-Tg-bovg-IP2887-Ag-2 Bovine HBG2 protein Bovine
GM-Tg-equg-IP2887-Ag-1/ GM-Tg-equg-IP2887-Ag-2 Equine HBG2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP2887-Ag-1/ GM-Tg-hg-IP2887-Ag-2; GM-Tg-rg-IP2887-Ag-1/ GM-Tg-rg-IP2887-Ag-2;
GM-Tg-mg-IP2887-Ag-1/ GM-Tg-mg-IP2887-Ag-2; GM-Tg-cynog-IP2887-Ag-1/ GM-Tg-cynog-IP2887-Ag-2;
GM-Tg-felg-IP2887-Ag-1/ GM-Tg-felg-IP2887-Ag-2; GM-Tg-cang-IP2887-Ag-1/ GM-Tg-cang-IP2887-Ag-2;
GM-Tg-bovg-IP2887-Ag-1/ GM-Tg-bovg-IP2887-Ag-2; GM-Tg-equg-IP2887-Ag-1/ GM-Tg-equg-IP2887-Ag-2
Products Name HBG2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name HBG2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HBG2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.